Low hepatic clearance of peptide YY
in the perfused rat liver.
The agreement includes exclusive commercial rights to issued United States Patent 5,604,203, which relates to analogs of Peptide YY
, or peptide derivatives, and uses thereof as therapeutic agents in the treatment of gastroenterological disorders; issued United States Patents 6,013,633, 6,235,718 and 6,737,408, which relates to compounds for control of appetite; and United States Patent 6,046,167, which relates to analogs of Peptide YY
El Akkary and his colleagues noted that an increase in peptide YY
might explain the findings.
is a naturally produced hormone associated with the modulation of appetite circuits in the brain.
Results were presented on the effects of EndoBarrier on two gastrointestinal hormones, gut peptides glucagon-like peptide-1 (GLP-1) and peptide YY
(PYY), and other diabetes measures.
Previous studies on that gut hormones, such as peptide YY
(PYY) and glucagon-like peptide (GLP-1), has shown that their release after a meal acts on the brain and induces satiety and meal termination.
As food enters your stomach, it stimulates production of two hormones - peptide YY
and oxyntomodulin - that create a feeling of fullness.
A study of meal-stimulated responses of insulin, ghrelin, peptide YY
, glucagon-like-peptide-1, and pancreatic polypeptide in humans and rodents following different bariatric surgical techniques found that gastric bypass patients had early and exaggerated insulin responses, potentially mediating the improved glycemic control in patients with diabetes (Ann.
Bothell, WA) announced it has acquired exclusive worldwide rights to the Cedars-Sinai Medical Center (Los Angeles, CA) (CSMC) Peptide YY
patent, patent applications, and proprietary know-how estate to support ongoing commercialization efforts of Nastech's investigational PYY 3-36 Nasal Spray for Obesity.
In addition, animal studies have shown that the fermentation of Hi-maize resistant starch in the large intestine turns on the genes that make satiety hormones glucagon-like peptide-1 (GLP-1) and peptide YY
(PYY), and that these hormones remained elevated for 20+ hours.