Shine, "Neuropeptide Y and peptide YY
have distinct roles in adult mouse olfactory neurogenesis," Journal of Neuroscience Research, vol.
Ghrelin levels dropped, but peptide YY
levels did not change significantly.
is a naturally occurring hormone that is believed to function as a physiologic inhibitor of food intake.
Koopmans, "Comparison of the effects of Roux-en-Y gastric bypass and ileal transposition surgeries on food intake, body weight, and circulating peptide YY
concentrations in rats," Obesity Surgery, vol.
Le Roux et al., "Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY
, glucagon-like peptide 1, ghrelin, and leptin," American Journal of Clinical Nutrition, vol.
It has been proposed that differences in the secretion of gut hormones (ghrelin, GLP1, peptide YY
) occurring after SG or RYGB may play a pivotal role in diabetes regression by acting on appetite [41, 42], improving insulin sensitivity, and restoring the first phase of insulin secretion [23,27,28], all effects which, concomitantly to weight loss, participate to the improvement of diabetes.
The use of a duodenal-jejunal bypass liner (DJBL) not only improves hemoglobin [A.sub.1c] and aids weight loss, but also appears to increase levels of glucagons like peptide--l (GLP-1) and peptide YY
while in place, according to the findings of a small study.
And levels of an appetite stopper called peptide YY
have been shown to increase five times as much in response to food among gastric bypass patients compared with levels in people who didn't get the surgery.
(Bothell, WA) has patented pharmaceutical compositions and methods comprising at least one peptide YY
compound and one or more intranasal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY
, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
Formerly obese patients who had undergone Roux-en-Y gastric bypass had increased levels of peptide YY
(PYY) and glucagon-like peptide 1 (GLP-1) and exaggerated insulin responses immediately following a meal.
(PYY) and ghrelin are gastrointestinal tract-derived hormones involved in the short- and long-term regulation of food intake and energy balance (1, 2).