peptide T

peptide T

A short polypeptide derived from the HIV envelope protein gp120, which blocks binding and infection by HIV strains that infect cells via the CCR5 receptor. Peptide T was studied as a possible AIDS therapy, but failed in clinical trials.

peptide T,

n a biological substance administered intranasally, it may block the spread of HIV infection and combat related neurologic dysfunction.
References in periodicals archive ?
The protein, dubbed Peptide T, was isolated from the HIV envelope protein and is being tested on Swedish and U.
At a seminar last week, the NIMH investigators described evidence suggesting that Peptide T may protect brain and immune cells by mimicking a naturally occurring peptide -- vasoactive intestinal peptide (VIP).
Brenneman, VIP and Peptide T similarly protected mouse neurons in laboratory cultures from dying after exposure to low concentrations of the HIV envelope protein.
Peptide T may act at only one of those subtypes, she notes.
A preliminary clinical trial of five patients in the early stages of AIDS injected with Peptide T for 30 days resulted in all the subjects reporting more energy, says Peter Bridge of NIMH.