peptidase


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Related to peptidase: signal peptidase

peptidase

 [pep´tĭ-dās]
any of a subclass of proteolytic enzymes that catalyze the hydrolysis of peptide linkages.

pep·ti·dase

(pep'ti-dās),
Any enzyme capable of hydrolyzing a peptide bond of a peptide, for example, carboxypeptidases, aminopeptidases.
Synonym(s): peptide hydrolase

peptidase

(pĕp′tĭ-dās′, -dāz′)
n.

pep·ti·dase

(pep'ti-dās)
Any enzyme capable of hydrolyzing one of the peptide links of a peptide (e.g., carboxypeptidases, aminopeptidases).

peptidase

An enzyme that hydrolyses (see HYDROLYSIS) protein fragments (PEPTIDES), breaking them down to AMINO ACIDS.

peptidase

an enzyme present in PANCREATIC JUICE that releases free AMINO ACIDS from POLYPEPTIDE CHAINS. EXOPEPTIDASES split off terminal amino acids, whereas ENDOPEPTIDASES split links within the chain.
References in periodicals archive ?
Vandekerckhove et al., "Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4," Cardiovascular Research, vol.
The identification of peptidases of the gastric fluid of the American lobster was carried out by comparing the electrophoresis composition of control sample with the peptidase class-specific inhibitor-treated samples (Fig.
Doty et al., "Dipeptidyl peptidase IV inhibitor treatment stimulates [beta]-cell survival and islet neogenesis in streptozotocin-induced diabetic rats," Diabetes, vol.
niger acid proteinase A or aspergillopepsin II) was insensitive to pepsin-type proteinase inhibitors, such as DAN, EPNP and pepstatin A, it continued to attract our attention and was long been thought to be a kind of non-pepsin type (or pepstatin-insensitive) aspartic peptidase. (166-169) Recently it was shown not to be an aspartic peptidase but a glutamic peptidase which has a catalytic Glu residue at the active site and thus renamed aspergilloglutamic peptidase.
Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of Type 2 diabetes.
Tokyo, Japan, June 15, 2006 - (JCN) - Ono Pharmaceutical and Banyu Pharmaceutical have obtained positive results in the recent clinical trials of sitagliptin, a dipeptidyl peptidase IV (DPP4) inhibitor.
(OSI) Prosidion's lead compound, PSN9301, is a Dipeptidyl Peptidase IV (DPIV) inhibitor currently in Phase II clinical trials.
A protein having "multifunctional activity," is defined herein as including at least one of a chymotrypsin, trypsin, collagenase, elastase or exo peptidase activity or asialo GM.sub.1 ceramide binding activity.
Despite this change, HAP is an active protease with distinct properties, and together with a series of cysteine and metallo-proteases and a dipeptidyl peptidase, provides attractive focus for antimalarial drug development.
Oncopeptides AB (STO:ONCO), a pharmaceutical company developing drugs for the treatment of cancer, announced on Wednesday that data from its phase 1/2 O-12-M1 study evaluating melflufen, a lipophilic peptide-conjugated alkylator belonging to the novel class of peptidase enhanced cytotoxics, in the treatment of relapsed/refractory multiple myeloma (RRMM), have been selected for poster presentation at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting taking place between 31 May 2019 to 4 June 2019 in Chicago.