peptic duodenitisA condition caused by chronic exposure to excess hydrochloric acid, which is characterised by inflammation, and most prominent in the duodenal bulb (D1), associated with Helicobacter pylori infection, chronic active gastritis and peptic ulcer disease. Peptic duodenitis is at the banal end of the spectrum of upper GI inflammation, at the other end of which is peptic ulcer disease.
Erythema (blood is shunted to the tips of the villi), mucosal friability, regional nodularity (Brunner’s gland hyperplasia). There is often a poor correlation between endoscopy and histology; extreme cases are eroded and ulcerated.
Coeliac disease, Crohn’s disease, drug-induced inflammation, parasites, ulcerative colitis.