pepsinogen


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Related to pepsinogen: trypsinogen

pepsinogen

 [pep-sin´o-jen]
a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pep·sin·o·gen

(pep-sin'ō-jen), [MIM*169700]
A proenzyme or zymogen formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 44 amino acyl residues from pepsinogen to form active pepsin.
Synonym(s): propepsin
[pepsin + G. -gen, producing]

pepsinogen

/pep·sin·o·gen/ (pep-sin´ah-jin) a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pepsinogen

(pĕp-sĭn′ə-jən)
n.
The inactive precursor to pepsin, formed in cells of the mucous membrane of the stomach and converted to pepsin by autocatalysis in the presence of hydrochloric acid.

pepsinogen

[pəpsin′əjən]
Etymology: Gk, pepsis + genein, to produce
a zymogenic substance secreted by pyloric and gastric chief cells. It is converted to the enzyme pepsin in an acidic environment, as in the presence of hydrochloric acid produced in the stomach.

pep·sin·o·gen

(pep-sin'ŏ-jen)
A proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin.
Synonym(s): propepsin.
[pepsin + G. -gen, producing]

pepsinogen

A biochemically inert substance produced by the cells of the stomach lining (gastric mucosa) that is converted to PEPSIN by the action of hydrochloric acid.

pepsinogen

a precursor of PEPSIN in the vertebrate stomach which, in the presence of hydrochloric acid (also secreted by the OXYNTIC CELLS in the stomach wall), gives rise to more active pepsin, which itself activates pepsinogen. The reaction is thus auto catalytic.

pepsinogen

a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

plasma pepsinogen
high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants.
References in periodicals archive ?
Miki K, Miki K, Ichinose M, Yahagi N (1977) Efficiency of gastric screening system using serum pepsinogen test.
In 1983 we succeeded to determine the structure of human pepsinogen A gene using the Maxam-Gilbert method and showed that the gene was composed of nine exons separated by eight introns.
Using low pepsinogen 1:2 ratio as a marker of atrophy, 6/14 (43%) of patients with intestinal metaplasia did not have atrophy, and none of the patients with intestinal metaplasia had atrophy as assessed by low serum gastrin-17.
Evaluation of a micro method for the routine determination of serum pepsinogen in cattle.
Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies.
The etiology of many non-bacterial gastric ulcer results from imbalance between irritator agents such as ethanol, NSAID, HCI, pepsinogen secretion, and protective agents like mucus, bicarbonate, prostaglandins; the therapeutic approach involves treatment with agents that restore this equilibrium.
Testing for both serum pepsinogen status and antibodies to Helicobacter pylori may be a good way to screen patients who are at risk for gastric cancer, according to the results of a prospective cohort study.
NEW YORK -- Pepsin or pepsinogen is present in the middle-ear fluid aspirates of many children with chronic or recurrent otitis media, but there appears to be no increase in symptoms of reflux in these children, Judith Lieu, M.
It was demonstrated recently that asymptomatic carriers of anti-HP antibodies have levels of pepsinogen A (PGA) and pepsinogen C (PGC) higher than those of serum-negative subjects, suggesting higher prevalence of chronic gastritis [17].
Carmel et al[7] found that 11 (58%) of 19 patients who had poor absorption of protein-bound Cbl had at least one of the following gastric dysfunctions: decreased gastric acid secretion (50%); elevated serum gastrin level (25%); and an abnormal pepsinogen ratio of 1:2 (40%), whereas in controls, 8 (31%) of 26 had gastric dysfunctions.
This action increases pepsinogen and gastrin and lowers pepsin and HCl.