pepsinogen


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Related to pepsinogen: trypsinogen

pepsinogen

 [pep-sin´o-jen]
a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.

pep·sin·o·gen

(pep-sin'ō-jen), [MIM*169700]
A proenzyme or zymogen formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 44 amino acyl residues from pepsinogen to form active pepsin.
Synonym(s): propepsin
[pepsin + G. -gen, producing]

pepsinogen

(pĕp-sĭn′ə-jən)
n.
The inactive precursor to pepsin, formed in cells of the mucous membrane of the stomach and converted to pepsin by autocatalysis in the presence of hydrochloric acid.

pep·sin·o·gen

(pep-sin'ŏ-jen)
A proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin.
Synonym(s): propepsin.
[pepsin + G. -gen, producing]

pepsinogen

A biochemically inert substance produced by the cells of the stomach lining (gastric mucosa) that is converted to PEPSIN by the action of hydrochloric acid.

pepsinogen

a precursor of PEPSIN in the vertebrate stomach which, in the presence of hydrochloric acid (also secreted by the OXYNTIC CELLS in the stomach wall), gives rise to more active pepsin, which itself activates pepsinogen. The reaction is thus auto catalytic.
References in periodicals archive ?
Cost-effectiveness of combined serum anti- Helicobacter pylori IgG antibody and serum pepsinogen concentrations for screening for gastric cancer risk in Japan.
[9.] Kekki M, Samloff IM, Varis K, Ihamaki T (1991) Serum pepsinogen I and gastrin in screening of severe atrophic corpus gastritis.
In multivariate analysis using unconditional logistic regression (Table 2), a statistically significant increase in risk was demonstrated in smokers, in patients with a history of ever having consumed alcohol on a regular basis, and in patients with markers of atrophy (low pepsinogen 1:2 ratio and low gastrin-17).
Pepsinogen is secreted by the chief cells of the stomach and is converted to pepsin in the acid medium.
It increases the pH around the parasites so as to avoid the action of gastric acids or pepsin on its cuticle [49, 80, 106], so there is an inhibition in the transformation of pepsinogen, produced in the principal cells of the gastric glands, to pepsin.
For example, measurable pepsinogen concentrations were below the normal reference ranges in a recent prospective study of 24 children aged 2-16 years (Otolaryngol.
Antibodies to Helicobacter pylori and pepsinogen levels in children from Costa Rica: comparison of two areas with different risks for stomach cancer.
Pepsinogen is activated to pepsin by hydrochloric acid produced in the stomach.
Antibodies directed against prostatic-specific antigen, pepsinogen II, cathepsin E, and salivary amylase were used to exclude the possibility that the mucinous area represented a metastasis from a primary tumor in the prostate, digestive tract, or salivary glands, respectively.