pepsin


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pepsin

 [pep´sin]
a proteolytic enzyme that is the principal digestive component of gastric juice. It acts as a catalyst in the chemical breakdown of protein to form a mixture of polypeptides; it is formed from pepsinogen in the presence of acid or, autocatalytically, in the presence of pepsin itself. Pepsin also has milk-clotting action similar to that of rennin and thereby facilitates the digestion of milk protein.

pep·sin

(pep'sin),
A group of closely related aspartic proteinases. Pepsin A is the principal digestive enzyme of gastric juice, formed from pepsinogen; it hydrolyzes peptide bonds at low pH values (is alkali-labile), preferably adjacent to phenylalanyl and leucyl residues, thus reducing proteins to smaller molecules (referred to as proteoses and peptones); pepsin B (gelatinase) is similar to pepsin A, but formed from porcine pepsinogen B and has a more restricted specificity; pepsin C (gastricsin is human pepsin C) is also similar to pepsin A, and structurally related to it, having a more restricted specificity.
[G. pepsis, digestion]

pepsin

also

pepsine

(pĕp′sĭn)
n.
1. A digestive enzyme found in gastric juice that catalyzes the breakdown of protein to peptides.
2. A substance containing pepsin, obtained from the stomachs of hogs and calves and used as a digestive aid.

pepsin

A generic term for any of the gastric proteases that are released by gastric chief cells as proenzymes (pepsinogen).

pep·sin

(pep'sin)
The enzyme produced by the stomach for the digestion of protein.
[G. pepsis, digestion]

pepsin

A digestive ENZYME whose precursor PEPSINOGEN is secreted by cells in the stomach lining. Pepsin breaks down protein to PEPTIDES. See also PEPTIDASE.

pepsin

an enzyme secreted in the inactive form PEPSINOGEN by chief or peptic cells in the gastric pits of the stomach of vertebrates, and which breaks down proteins in acid solution into short polypeptide chains which are subsequently broken down further by PEPTIDASES.
References in periodicals archive ?
It is further indicated by the pepsin increase that occurred on 12 DPH which could indicate that this species has the potential to perform co-feed studies from an early age and see the possibility of bringing forward the time of weaning.
The activity of enzyme treated with trypsin ramain 95%, but the enzyme in pepsin almost inactive after 1h.
Aspartic proteases (Aps) have been connected to a wide range of physiological functions, including mammalian digestion of nutrients (e.g., chymosin and pepsin A), defense against pathogens, yeast virulence (e.g., candidapepsins), metastasis of breast cancer (e.g., cathepsin D), pollen-pistil interactions (e.g., cardosin A), control of blood pressure (e.g., renin), degradation of hemoglobin by parasites (e.g., plasmepsins), and maturation of HIV proteins (retropepsin) [11].
IPF is the active drug substance of ITV-1 and is a purified extract of porcine pepsin. ITV-1 has been shown to modulate the immune system.
Extraction, purification and characterization of fish pepsin: a critical review.
These include chief cells, which produce a key digestive enzyme called pepsin, and parietal cells.
This strain V1 were identified by phenotypic and biochemical methods, were tested for their antimicrobial activity against Staphylococcus aureus, Listeria innocua, Listeria ivanovii and was evaluated for certain properties relevant to probiotic including : acid pH, bile salts, pepsin resistance, hemolytic activity and antibiotics sensitivity.
However, ovomucoid is broken down by pepsin in the stomach in both its unheated and heated states [20]; thus, its trypsin-inhibiting effects may not occur in the gastrointestinal tract.
The proteases that are normally used in Cucurbitaceae seed protein hydrolysis come from animals (Pepsin and Trypsin) or fungi and bacteria (Alcalase, Neutrase, and Flavourzyme) and they can be classified as endoproteases (Alcalase, Pepsin, and Trypsin), exoproteases, and complex mixtures of endo- and exoproteases (Flavourzyme).
Herbal formula of these supplements supports functions of gastric glands which produce pepsin and support enzyme activities that help in digestion.
My poor old stomach/gut is in big trouble, even though I take probiotics, digestive enzymes, betaine, and pepsin. I have Atrial Fibrillation and Atrial Flutter and need to know if any of the ingredients in the Integrative Digestive Formula will affect my heart.--Lorna F., via email