pentylenetetrazol


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Related to pentylenetetrazol: Metrazol

pen·ty·lene·tet·ra·zol

(pen'ti-lēn-tet'ră-zol),
A powerful CNS stimulant; has been used to cause generalized convulsion in the shock treatment of emotional states and as a respiratory stimulant; mainly used in experimental studies of seizure mechanisms and the search for new anticonvulsant drugs.

pentylenetetrazol

(pĕn′tə-lēn′tĕt′rə-zôl′, -zōl′, -zŏl′)
n.
A drug, C6H10N4, that is a central nervous system and respiratory stimulant, used experimentally primarily to induce seizures for pharmaceutical research.
References in periodicals archive ?
Effect of anandamide on malondialdehyde (MDA), nitric oxide, and reduced glutathione (GSH) in brain of rats subjected to pentylenetetrazol (PTZ)-induced kindling.
Yin et al., "Involvement of over-expressed BMP4 in pentylenetetrazol kindling-induced cell proliferation in the dentate gyrus of adult rats," Biochemical and Biophysical Research Communications, vol.
Time-course for induction of kindling (n=32) after repeated pentylenetetrazol (35 mg/kg, ip) administration.
Reduced glutathione P value (nmol/mg of protein) 1 1.012 [+ or -] 0.06 -- 2 0.344 [+ or -] 0.05 (a) 0.009 3 0.899 [+ or -] 0.07 (b) 0.049 4 0.923 [+ or -] 0.07 (c) 0.009 5 0.952 [+ or -] 0.07 (c) 0.008 TBARS: Thiobarbituric acid reactive substance; PTZ: Pentylenetetrazol; SVP: Sodium valproate (200 mg-kg); LYC: Lycopene (2 and 4 mg-kg).
The effect of hydroalcoholic extract of heracleum persicum on pentylenetetrazol induced seizure in mice.
The solution of pentylenetetrazol was prepared by dissolving 560 mg of pentylenetetrazol in 20 ml of distilled water, at room temperature.
Therefore, the present study investigated the effects of 4TRP on convulsions induced by mercaptopropionic acid (3-MP) and seizures induced by pentylenetetrazol (PTZ) via behavioural and electroencephalographic methods and investigated the molecular mechanisms involved in these effects.
Latentcy time, time to death, mortality rate and tonic clonic convulsions rate induced by pentylenetetrazol were determined for 10 mice of each group (Zapata-Sudo et al.
The present study was designed to evaluate the anxiolytic, antidepressant, sedative, and anticonvulsant effects produced by extracts of Byrsonima crassifolia in ICR mice by using different models, such as the elevated plus maze, the forced swimming test, the pentobarbital potentiation test, and the seizures-induced pentylenetetrazol. Furthermore, their influence on motor activity test was also studied.