Monotherapy being no longer effective, we suggest multidrug therapy while granting priority to pentavalent antimonials (glucantime or pentostam
) as first-line drugs in combination with second-choice compounds including paromomycin.
Gurei et al18 in a clinical trial compared the efficacy of intra-lesional sodium stibogluconate (pentostam
) with cryotherapy in the treatment of CL.
Turkiye'de sodyum stiboglukonatin "pentostam
" markali ticari formu bulunurken meglumin antimonatin ticari urunu "glucantime" dir.
Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam
) against Leishmania donovani in immunodeficient scid mice.
Ward, "The use of pentostam
liposomes in the chemotherapy of experimental leishmaniasis," Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.
Actually, the treatment of leishmaniasis is performed with some drugs such as liposomal amphotericin B (for visceral leishmaniasis) and pentavalent antimonial compound sodium stibogluconate (Pentostam
) (for cutaneous leishmaniasis), although there are still no preventive medications or vaccinations for the disease .
In the case of leishmaniasis, the compounds Pentostam
and Glucantime were also considered prooxidant agents, because the proposed mode of action is the inhibition of trypanothione reductase and induction of the efflux of thiols .
Coons, "Leishmania donovani: isolation and characterization of sodium stibogluconate (Pentostam
)-resistant cell lines," Experimental Parasitology, vol.
Ozbilge et al., "Efficacy of cryotherapy and intralesional pentostam
in treatment of cutaneous leishmaniasis," Journal of the Egyptian Society of Parasitology, vol.
The treatments currently in use as prime therapy for leishmaniasis include meglumine antimoniate (Glucantime), in addition to pentavalent antimonials sodium stibogluconate (Pentostam
), but they are harmful to some extent, require prolong parenteral administration courses and have powerful side effects .
This finding relates directly to the first-line treatment of leishmaniasis with pentostam
and glucantime, since both drugs release Sb[(OH).sub.3] as the active agent in the macrophage environment (Gourbal et al., 2004).
Placebo-controlled clinical trial of sodium stibogluconate (Pentostam
) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala.