pentosan polysulfate


Also found in: Wikipedia.

pentosan polysulfate

Oncology An angiogenesis inhibitor that may block effects of growth factors on endothelial cells and protect the GI tract against RT Urology A drug used to relieve bladder pain due to interstitial cystitis. See Angiogenesis inhibitor.
References in periodicals archive ?
The small molecules are further classified into pentosan polysulfate, quinacrine, amphotericin B, and others.
The use of pentosan polysulfate has been primarily studied in interstitial cystitis.
Pentosan polysulfate sodium (PPS), intravesical dimethyl sulphoxide (DMSO), and many oral agents are used despite a lack of FDA approval (e.g., antihistamines, tricyclic antidepressants, antispasmodics, and steroids), as well as hydrodistension, botulinum toxin injections, neuromodulation, and even cystectomy are methods currently used in treatment.9
The role of pentosan polysulfate in the treatment approaches for interstitial cystitis.
Zheng et al., "Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice," Laboratory Investigation, vol.
Paradigm Biopharmaceuticals (ASX: PAR) has successfully dosed the first patient in the Phase 2b clinical trial for pentosan polysulfate sodium (PPS) as a treatment for knee osteoarthritis, Proactive Investors reported on Monday.
The sole medication approved by the Food and Drug Administration for IC is pentosan polysulfate sodium (Elmiron), and it should be reserved for the minority of patients who don't experience significant improvement after giving the diet a reasonable shot, Dr.
Nickel, et al., pentosan polysulfate sodium was shown to improve pain, urgency, and frequency over the control group (Urology.
Various treatment approaches maybe indicated for RHC, such as bladder irrigation; intravesical treatment with alum or formalin and hyaluronic acid; corticoids; oral estrogen, sodium pentosan polysulfate, and hyperbaric oxygen therapy; factor VIIa/factor VIII and epsilon-aminocaproic acid; hydrodistension of the bladder; embolization or ligation of the internal vesical and iliac arteries; and, as a last alternative, cystectomy with urinary diversion [4].
Pentosan polysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome: insights from a randomized, double-blind, placebo-controlled study.
Among linear polyanions, glycosaminoglycans (GAGs) and sulfated polysaccharides such as pentosan polysulfate or heparan sulfate were shown to influence prion conversion