The nicotinic acetylcholine receptor: the founding father of the pentameric
ligand-gated ion channel superfamily.
CRP is a pentameric
23 kDa member of the pentraxin family of plasma proteins discovered by Tillett and Francis in 1930.7 Named for its ability to precipitate the C-polysaccharide of Streptococcus pneumonia.
Currently, the paper-based technique can detect anti-ABO antibodies, but those are normally high concentration, pentameric
, high-avidity IgM antibodies that can cross-link RBCs.
Based on the well-known structure and assembly of SMC monomers into pentameric
ring complexes, it appears unlikely that the predicted SMC domain in Nesprin-2 fulfills the role of a classical SMC protein.
The mRNA of IAP2 protein belongs to group 3 of ARE proteins, containing 3 pentameric
AUUUA repeats .
These receptors are pentameric
proteins composed of different subunits surrounding a central chloride ion-selective channel gated by GABA.
nAChRs are members of a family of ligand-gated, pentameric
ion channels that are tightly arranged around a central pore .
Both CT and LT are composed of enzymatically active A subunit which possesses ADP-ribosylating activity and pentameric
B subunits which possesses monosialoganglioside (GM1) receptor-binding site.
PTX3 is a prototype of long pentraxins; a large molecule with molecular weight of 40.6kD characterized by a pentameric
structure, which can result in increased retention during uremia (15).
Gal-3, existing as a monomer in solution, produces a pentameric
structure through self-associated intermolecular interactions and mediates crosslinking of proteins, forming a lattice organization (108, 110,111).
IgM antibody by virtue of its large pentameric
structure has five Fc fragments per molecule and will fulfil this requirement.
AV0328 is a synthetic pentameric
oligosaccharide of b-1-6-linked D-glucosamine sugars conjugated to tetanus toxoid that elicits a protective antibody response against a large number of microbial pathogens associated with infections.