pentagastrin test

pen·ta·gas·trin test

an alternative to histamine for stimulation of acid secretion in gastric analysis.

pentagastrin test

(for gastric function) a test comparing basal acid output with a peak acid output. After the patient fasts overnight, a basal acid output and its pH are obtained for secretion of stomach acid. Then pentagastrin is administered into the stomach through a nasogastric tube and maximal acid output and peak acid output values are obtained. Also called pentagastrin stimulation test.

pentagastrin test

GI disease A test in which gastric acid secretion–GAS is stimulated with pentagastrin, a synthetic analogue of gastrin; GAS ↑ 10 mins post-injection, peaks at 20-30 mins, and lasts for < 2 hrs; the peaks in GAS are similar to those evoked by histamine–once used for the same purpose, with fewer adverse effects; PT is used to exclude achlorhydria in Pts with gastric ulcers

pentagastrin test

A test of the acid production by the stomach. An injection of a synthetic pentapeptide substance, pentagastrin is given, and an hour later the fasting stomach contents are withdrawn through a nasogastric tube.
References in periodicals archive ?
In clinical practice, a patient with a calcitonin concentration higher than 10 ng/L should undergo a pentagastrin test to exclude MCT.
The pentagastrin test was also carried out on a child who presented with the clinical signs of MTC at the age of 6 months (persistent diarrhea, calcitonin concentration of 28 ng/L).
We propose that high values do not necessarily indicate a need for a pentagastrin test, especially in infants less than 1 year: the basal value should be confirmed several weeks later before performing this type of additional testing.
The pentagastrin test for CT is the most widely used provocative test for the diagnosis of MTC and for assessment of cure after surgery for MTC in patients with undetectable basal CT concentrations.
In MTC patients there was no significant difference between men and women regarding CT baseline, CT peak, and CT% values after the pentagastrin test (Table 1).
In addition, the pentagastrin test is useful for detecting hereditary MTC carriers in families where no RET mutations are identifiable (19).
24), the serum dosage of endogenous GT plus pentagastrin achieved during the pentagastrin test in their study was -20-fold higher than the GT basal concentration.
Despite these limitations, the omeprazole test can be used when the pentagastrin test is contraindicated or refused on the basis of the unpleasant side effects and in countries where pentagastrin is not available.
As the authors point out, the ability to detect these mutations has freed clinicians from the more invasive, less reliable pentagastrin test (which increases serum calcitonin concentrations) as a predictor for this set of late-onset diseases, mainly medullary thyroid carcinoma (MTC).