The pentagastrin test was also carried out on a child who presented with the clinical signs of MTC at the age of 6 months (persistent diarrhea, calcitonin concentration of 28 ng/L).
We propose that high values do not necessarily indicate a need for a pentagastrin test, especially in infants less than 1 year: the basal value should be confirmed several weeks later before performing this type of additional testing.
The pentagastrin test for CT is the most widely used provocative test for the diagnosis of MTC and for assessment of cure after surgery for MTC in patients with undetectable basal CT concentrations.
In MTC patients there was no significant difference between men and women regarding CT baseline, CT peak, and CT% values after the pentagastrin test (Table 1).
In addition, the pentagastrin test is useful for detecting hereditary MTC carriers in families where no RET mutations are identifiable (19).
24), the serum dosage of endogenous GT plus pentagastrin achieved during the pentagastrin test in their study was -20-fold higher than the GT basal concentration.
Despite these limitations, the omeprazole test can be used when the pentagastrin test is contraindicated or refused on the basis of the unpleasant side effects and in countries where pentagastrin is not available.
As the authors point out, the ability to detect these mutations has freed clinicians from the more invasive, less reliable pentagastrin test
(which increases serum calcitonin concentrations) as a predictor for this set of late-onset diseases, mainly medullary thyroid carcinoma (MTC).