penicillinase


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

penicillinase

 [pen″ĭ-sil´ĭ-nās]
an enzyme produced by certain bacteria that inactivates penicillin, so that such bacteria have increased resistance to the antibiotic; a purified form from Bacillus cereus is used in treatment of reactions to penicillin.

pen·i·cil·li·nase

(pen'i-sil'i-nās),
1. Synonym(s): β-lactamase
2. A purified enzyme preparation obtained from cultures of a strain of Bacillus cereus; formerly used to treat slowly developing or delayed penicillin reactions.

penicillinase

/pen·i·cil·lin·ase/ (pen″ĭ-sil´ĭ-nās) a β-lactamase preferentially cleaving penicillin.

penicillinase

(pĕn′ĭ-sĭl′ĭ-nās′)
n.
Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.

penicillinase

[pen′əsil′ənās]
an enzyme elaborated by certain bacteria, including many strains of staphylococci, that inactivates penicillin and thereby promotes resistance to the antibiotic. A purified preparation of penicillinase, derived from cultures of saprophytic spore-forming Bacillus cereus, is used in the treatment of adverse reactions to penicillin. Also called beta-lactamase.

penicillinase

An enzyme present in some bacteria, especially STAPHYLOCOCCI, that inactivates penicillins, by HYDROLYSIS of the beta-lactam bond, so that the organisms possess resistance to the drug. Also known as beta-lactamase.

penicillinase

enzyme inactivating penicillin; produced by some staphylococci

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

penicillinase

an enzyme produced by bacteria that inactivates penicillin, thus increasing resistance to the antibiotic; a purified form from Bacillus cereus is used in the treatment of reactions to penicillin.
References in periodicals archive ?
A previous study at our institution found discrepancies between Phoenix nitrocefin and a chromogenic cephalosporin test in the determination of penicillinase activity (14), which led us to prospectively investigate these differences and to compare results with Phoenix MIC values for penicillin and ampicillin and to compare results with ampicillin disk diffusion.
The enzyme assay result can be explain by assuming that both flavonol (galangin) and flavone (apigenin), which shared OH at 5 and 7 carbon position, can inhibit penicillinase activity (Eumkeb et al.
The ability of flavonoids to inhibit the in vitro activity of penicillinase and [beta]-lactamases varied considerably.
2002) have confirmed that EGCg inhibits the penicillinase produced by S.
TEM-1] gene that coded for narrow-spectrum penicillinase and a [bla.
Although penicillins are considered safe during pregnancy, the fact that Bacillus anthracis strains may have penicillinase activity led to the recommendation that amoxicillin be used for prophylaxis only if the specific strain was shown to be penicillin sensitive.
Comparison between methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus Strain and major resistance mechanism * BORSA/novel methicillinase [+ or -] MSSA/penicillinase penicillinase production hyperproduction PBP2a detection (e.
Therefore, it is all the more surprising that genes commonly found on plasmids in the latter bacterial genus, such as bla for penicillinase production and aac6'-aph2" for resistance to nearly all commercially available aminoglycosides, have not yet emerged in streptococci.
coli and 2 strains of Citrobacter koseri were positive through the P/Case TEST for production of penicillinase, cephalosporinase, or both (Table 1).
Until 2000, most extended spectrum beta-lactamines (ESBLs) were mutants of classical TEM and SHV plasmid-mediated penicillinases.

Full browser ?