penicillinase


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penicillinase

 [pen″ĭ-sil´ĭ-nās]
an enzyme produced by certain bacteria that inactivates penicillin, so that such bacteria have increased resistance to the antibiotic; a purified form from Bacillus cereus is used in treatment of reactions to penicillin.

pen·i·cil·li·nase

(pen'i-sil'i-nās),
1. Synonym(s): β-lactamase
2. A purified enzyme preparation obtained from cultures of a strain of Bacillus cereus; formerly used to treat slowly developing or delayed penicillin reactions.

penicillinase

(pĕn′ĭ-sĭl′ĭ-nās′)
n.
Any of several beta-lactamase enzymes that cleave the beta-lactam ring in penicillins. Penicillinases are found in many penicillin-resistant bacteria.

penicillinase

An enzyme present in some bacteria, especially STAPHYLOCOCCI, that inactivates penicillins, by HYDROLYSIS of the beta-lactam bond, so that the organisms possess resistance to the drug. Also known as beta-lactamase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.
References in periodicals archive ?
Etest (bioMerieux) was also used to determine the minimum inhibitory concentration (MIC) of penicillin and ampicillin on three isolates classified as penicillinase hyper-producers.
Figure 2: Cephalosporinase/penicillinase induced neutralization of 13 [beta]-lactam antibiotics which inhibit growth of Kocuria rhizophila ATCC 9341 on TSA contact plates Reference without With cephalosporinase cephalosporinase and penicillinase or penicillinase (medium contains (medium contains lecithin end Tween 80) lecithin.
Our findings were in agreement with other workers (24,26) who reported that Staphylococci (both penicillinase negative and positive) were highly susceptible to meropenem.
[10,11] On exploring use of ES - 31 antigens of M.tb[H.sub.37]Ra in stick penicillinase ELISA for the detection of seroreactivity in pulmonary and extrapulmonary TB, ES-31 showed good potential in detecting IgG antibody in TB Lymphnode, Tubercular meningitis and pulmonary TB.
aureus that produced penicillinase, a [beta]-lacta mase that deactivates penicillin by cleaving a bond in the b-lactam ring.
aureus produced a factor called penicillinase (or beta-lactamase), which degraded penicillin and decreased its effectiveness in treating Staph infections.
During these years, the bacterium acquired a plasmid containing a gene for the enzyme penicillinase, which destroys the penicillin molecule.
This germ could produce an enzyme, penicillinase, that destroyed the penicillin molecule.
In the gonococci, the chromosomally mediated expression of multiple resistance genes and the production of the penicillinase plasmid TEM-1 [beta]-lactamase are 2 independent mechanisms involved in a susceptible-to-resistant strain switch.
Penicillin and cephalosporins are not recommended for initial treatment due to the demonstration of a cephalosporinase and an inducible penicillinase in the anthrax genome.
Stability studies of the components of a prototype penicillinase (beta-lactamase)-linked ELISA kit.
Huletsky, "Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator," Antimicrobial Agents and Chemotherapy, vol.

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