In one of those studies, which was published this year in an allergy and asthma journal, 20 subjects with a history of penicillin allergy
agreed to direct oral amoxicillin rechallenge by an allergist, he said.
The study compared adults with a known penicillin allergy
to similar people without a known penicillin allergy
After adjusting for several known risk factors, the researchers found that a penicillin allergy
label was associated with a 69 percent increased risk of MRSA and a 26 percent increased risk of C difficile.
Torres et al., "Clinical evaluation of Pharmacia CAP system[TM] RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy
," Allergy, vol.
The parents (597) of children aged 4-18 years with a history of parent-reported penicillin allergy
completed an allergy questionnaire; 51% (302) of the children were categorized as low risk, and 100 of them completed allergy testing by using a standard three-tier testing process.
The second part of the study was conducted in 2014, and it prospectively included patients with a history compatible with IgE mediated penicillin allergy
, namely a history of urticaria/angioedema, anaphylaxis or rash during penicillin, amoxicillin or amoxicillin-clavulanic acid treatment.
Overdiagnosis of penicillin allergy
is not benign, Ramsey says.
There is no defined azithromycin paediatric dosage for the secondary prevention of rheumatic fever in penicillin allergy
. Azithromycin has however been dosed long term in clinical trials in children with cystic fibrosis.
(19) observed an association between levels of specific IgE, cytokines and polymorphisms of IL-4 C/T and IL-4R[alpha]Q576R in patients with penicillin allergy
. According to the authors, the allele LL-4R[[alpha].sup.*]Q576 was present more frequently in allergic patients than in control subjects.
This is a good time to mention that there is potential cephalosporin cross-sensitivity in patients with a true penicillin allergy
(4% to 10% of cases) that has been observed predominantly with first-generation cephalosporins.
There is also a "traffic-light" system identifying which antibiotics should not be given to patients with penicillin allergy
is one of the most commonly reported drug allergies worldwide.