SLC26A4 encodes a transmembrane protein termed as pendrin
. Subsequently, SLC26A4 mutations were also discovered in individuals with autosomal recessive nonsyndromic deafness associated with enlargement of the vestibular aqueduct (32).
It comprises of 21 exons and encodes pendrin
Czarnocka, "Thyroperoxidase, thyroglobulin, [Na.sup.+]/[I.sup.-] symporter, pendrin
in thyroid autoimmunity," Frontiers in Bioscience, vol.
, the most important example, helps to provide positive endocochlear potential and high-potassium environment in the endolymph.
NIS, located at the basolateral membrane of thyrocytes (27), transports iodide into the cells which is then transported across the apical membrane into the follicular lumen (or colloid) by different anion transporters, such as pendrin
and apical iodide transporter (28,29).
He, "Engineered pendrin
protein, an anion transporter and molecular motor," The Journal of Biological Chemistry, vol.
We then investigated how pendrin
causes airway inflammation, pinpointing the significance of the hypothiocyanite ([OSCN.sup.-]) production via the pendrin/DUOX/peroxidase pathway [9, 10].
Previous studies largely focused on the identification and regulation of apically expressed Cl- transporters, including Na+-Cl- cotransporter, Na+-K+-2Cl- cotransporter (NKCC1/NKCC2) and pendrin
, but mechanisms and regulation of Cl- transporters on basolateral membranes (i.e.
Dyshormonogenesis is often caused by mutations in the genes involved in the synthesis of thyroid hormone, such asiodotyrosinedeiodinase (IYD), dual oxidase 2 (DUOXA2), DUOX maturation factor 2 (DUOXA2), thyroglobulin (TG), thyroperoxidase (TPO), sodium/iodide symporter (MS), and pendrin
It is clear that airway epithelial cells can affect inflammation by producing cytokines that affect maturation and recruitment of eosinophils and other leukocytes.[sup] Ion channel regulator could be an effective strategy for treatment of asthma exacerbations.[sup], The results reported provide a basis for future studies aimed at developing and testing pendrin
inhibitors for use in asthma exacerbations.
The expression of NHE3, [H.sup.+]-ATPase and pendrin
was significantly higher among patients than in controls.
Investigators have developed assays for the detection of circulating mRNA species coding for thyroid peroxidase (TPO), the sodium iodine symporter (NIS), pendrin
(PDS), the thyrotropin receptor (TSHR) and Tg.