It is also important to investigate whether other treatments for HSV-1, such as penciclovir
, can be incorporated into controlled release vehicles created using the VASE method.
Natile, "Antiviral properties and cytotoxic activity of platinum (II) complexes with 1, 10-phenanthrolines and acyclovir or penciclovir
," Journal of Inorganic Biochemistry, vol.
It is absorbed in the intestine for conversion to its active form penciclovir
. All three nucleoside analogs can be used for herpes simplex treatment.
Herpes simplex virus resistance to acyclovir and penciclovir
after two decades of antiviral therapy.
Biotransformation of the antiviral drugs acyclovir and penciclovir
in activated sludge treatment.
Susceptibilities of herpes simplex viruses to penciclovir
and acyclovir in eight cell lines.
Famciclovir is a prodrug that is converted in vivo to penciclovir
, the active antiviral agent.
, valaciclovir, famciclovir, and ganciclovir and others) have been approved for treatment of HSV-1 infections worldwide (Galasso et al., 1997; Leung and Sacks, 2000; Brady and Bernstein, 2004).
Denavir (1% penciclovir
cream) is a highly selective and potent topical antiviral treatment indicated for the treatment of recurrent herpes labialis (cold sores) in adults and children 12 years of age and older.
During his career, he has played a major role in the development of antibiotics (penicillins, cephalosporins, quinolones), vaccines (Hepatitis A, Hepatitis B), antivirals (famciclovir, penciclovir
, pleconaril), and topical antimicrobials (Bactoban).
Prescription and over-the-counter topical antivirals, such as docosanol, acyclovir, and penciclovir
, speed healing by about half a day.
The patent was directed to a herpes drug called famciclovir which is converted into penciclovir
in the body.