DSG3

(redirected from pemphigus vulgaris antigen)

DSG3

A gene on chromosome 18q12.1 that encodes desmoglein 3, a component of intercellular desmosome junctions, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell–cell adhesion. It is expressed in the epidermis, tongue, tonsil and oesophagus.

Molecular pathology
Desmoglein 3 is the antigen targeted in the autoimmune blistering disease pemphigus vulgaris.
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References in periodicals archive ?
Stanley, "Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients," The Journal of Investigative Dermatology, vol.