pegylation


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pegylation

(pĕg′ĭ-lā′-shŭn)
The chemical linking of a drug (e.g., interferon) to polyethylene glycol. Pegylation increases the half-life of interferon.
References in periodicals archive ?
DARMSTADT, Germany, July 27, 2015 /PRNewswire/ -- Merck Millipore, the Life Science business of Merck, today announced a collaboration with celares GmbH to provide pegylation services to customers developing protein-based therapeutics and biosimilars.
The new services will leverage EMD Millipore's broad range of functionalized PEG products of different molecular weight and activation chemistry, as well as buffers, solvents and excipients, unit operations employed during the pegylation process and subsequent purification including tangential and normal flow filtration and chromatography.
Nektar and Affymax entered into a partnership in 2004 under which Nektar provides Affymax with its Advanced PEGylation Technology to develop Hematide.
MVP's new publication provides additional evidence for the immunologic advantages of protein conjugates synthesized with the company's improved PEGylation reagents (PharmaPEG([R]) conjugates).
Oren Hershkovitz will discuss PROLOR's experience applying its proprietary CTP and Reversible PEGylation technologies to significantly extend the duration of action of therapeutic proteins and peptides, focusing on PROLOR's potential treatments for obesity and multiple sclerosis.
PEGylation is an established method for improving drugs and nine PEGylated products are already approved for therapeutic use worldwide.
The company's senior management team includes inventors of the most successful drug delivery technology in pharmaceutical history, PEGylation, now responsible for more than $30 billion in drug sales worldwide.
Burlingame, CA) announced that, through its wholly-owned subsidiary, PolyMASC Pharmaceuticals Plc, the company has entered into a broad licensing agreement with Prolong Pharmaceuticals (Califon, NJ) for use of its proprietary OptiPEG PEGylation platform in the development and commercialization of PEGylated protein therapeutics.
Enzon's drug development programs utilize several approaches, including its cutting-edge proprietary customized linker-enhanced PEGylation technology and mRNA antagonists using the Locked Nucleic Acid (LNA) technology.
PolyTherics has applied its HiPEG(TM) site-specific PEGylation technology to interferon alpha to produce a product (HiPEG(TM) IFN alpha-2a) that has eight-fold higher activity than a marketed PEGylated interferon in vitro and a comparable half-life in a preclinical study.
Enzon's proprietary customized linker-enhanced PEGylation technology allows a soluble, more potent, and longer-lasting version of the drug, which may be administered weekly or once every three weeks.