pegylation


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pegylation

(pĕg′ĭ-lā′-shŭn)
The chemical linking of a drug (e.g., interferon) to polyethylene glycol. Pegylation increases the half-life of interferon.
References in periodicals archive ?
Prolong Pharmaceuticals is a privately held biopharmaceutical company focusing on the development and manufacturing of novel PEGylation based compounds.
Indeed, PEGylation of paclitaxel-loaded liposomes led to increased plasma and tumor levels of paclitaxel, in parallel decreased liver and spleen paclitaxel levels over Taxol or conventional paclitaxel liposomes and resulted in the best tumor growth inhibition [57].
Introduction and overview of peptide and protein PEGylation, Adv Drug Deliv Rev, 54, 453-456 (2002).
The OptiPEG platform, consisting of proprietary PEGylation technologies, potentially allows for improved dosing of biopharmaceuticals.
The successful PEGylation was confirmed by DLS where the size of the PLL-AuNPs was found to increase from 47.5 [+ or -] 0.3 nm (size by intensity) to 75.26 [+ or -] 0.76 nm while the zeta potential was found to decrease from +33 [+ or -] 2.5 mV to + 12.0 [+ or -] 3 mV, confirming the attachment of PEG onto the PLL-AuNP surface.
Our team of experts designs the most efficient processes for peptidic active pharmaceutical ingredients using innovative technologies such as PEGylation, lipidation, glycosylation, ligation, cyclization (multiple disulfide or lactam bridges).
Inhale offers three leading drug delivery platforms: a suite of technologies for the inhaleable delivery of macromolecules and small molecules for systemic and local lung delivery; supercritical fluid powder particle engineering to easily control particle size for a variety of drug delivery applications; and PEGylation for enhanced delivery performance of most major drug classes.
Surface PEGylation of the grafted polymer also enhances its stability in the extracellular matrix of oesophageal squamous cell carcinoma (OSCC) cells.
Small molecule injectables are expected to grow at a faster rate while drug delivery systems like liposomes, pegylation and depot injections are also expected to grow.
In conjunction, the company will continue to operate its 105,000-square-foot manufacturing and process development facility in Huntsville, Alabama that manufactures proprietary PEGylation compounds for its own clinical pipeline, as well as pharmaceutical partners.
Inhale is pioneering inhaleable delivery of macromolecules, supercritical fluids processing for powder particle production and advanced PEGylation. Inhale is collaborating with major pharmaceutical and biotech-nology companies, including Amgen, AstraZeneca, Aventis Behring, Biogen, Bristol-Myers Squibb, Glaxo-SmithKline, Lilly, Pfizer, Pharmacia, and Roche.
With specific adjustments (e.g., PEGylation) their half time can also be increased.