pederin


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pederin

(pĕd′ĕ-rĭn) [Fm. the genus name]
An organic compound secreted by certain blister beetles of the genus Paederus as a form of defense against predators. It causes a blistering rash on contact with human skin. The compound may actually be manufactured by bacteria that colonize the beetle rather than by the beetle itself. Pederin kills tumor cells in laboratory experiments.
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The beetle affects mostly the skin after contact with the body and releasing pederin toxins.
Kissing lesions' can occur after spreading of pederin to adjacent skin surfaces, usually flexural e.
2) Intense pain and temporary blindness have been reported when pederin is introduced into the eyes.
Ivan Pederin, "Odnos beckoga dvora prema crkvenoj uniji u Dalmaciji dvadesetih godina 19.
Trowell says some small, brightly-coloured staphylinid beetles, commonly known as whiplash beetles, secrete a potent defensive compound called pederin.
Pederin is a protein-synthesis inhibitor, and one of the most potent cytotoxins known to science.
It turns out that the beetles lack the enzymes required to synthesise pederin.
One or a combination of the vesicating chemicals pederin, pseudopederin, and pederone have been found in 20 species of Paederus (12) Pederin is the most common chemical of the three and is one of the most complex nonproteinaceous insect secretions known.
Paederus beetles do not release pederin as a defensive secretion and people are exposed to the chemical only when a beetle is accidentally crushed on the skin.
17) This eruption usually begins 24 to 72 hours after pederin contacts exposed human skin.
Dermatitis caused by cantharidin is generally less symptomatic than that caused by pederin because cantharidin blisters do not cause as intense burning or itching.
Some authors regard pederin as a natural mimic of vesicating warfare agents such as mustard and Lewisite.