On the breast,
peau d'orange nearly always indicates a cancerous lump underneath.
The earliest fundus finding of PXE is
peau d'orange, which occurs as the result of the accumulation of yellow material in the RPE and is seen more in the temporal macula.
Cellulifis: Non- 200 cases per *
Peau d'orange * Observed most necrotizing 100,000 appearance frequently inflammation of patient-years can be noted among middle- the skin and (Ellis (Ellis aged and subcutaneous Simonsen, van Simonsen et elderly (Ellis tissues.
In the era before Haagensen, surgeons advocated radical local excision of breast cancer including clear margins around all areas of
peau d'orange. This theory of breast cancer as a localised disease of the breast to be treated by surgery was later replaced by one of breast cancer being a systemic disease early in its course.
The skin lesions of NFD are typically symmetrical and are commonly distributed bilaterally between the ankles and mid-thighs, and between the wrists and mid-upper arms (Cowper, 2003); the lesions are described as papules or subcutaneous nodules that combine or fuse together to form erythematous to brawny hyperpigmented plaques with a
peau d'orange (skin of an orange) appearance (Cowper et al., 2001); the plaques have a "distinctive irregular edge resembling amoeboid projections" (Mackay-Wiggan, Cohen, Hardy, Knobler, & Grossman, 2003, p.55); and patients often complain of pruritis and burning pain in the affected areas (Cowper, 2003).
Skin involvement in NSF frequently presents on the extremities as erythematous papules or plaques, often with
peau d'orange surface changes and woody induration.
It presents with tan macules and papules that may have a "
peau d'orange" (orange peel) appearance.
Skin-colored to erythematous papules coalesce into brawny plaques with a
peau d'orange appearance.
Although it is rare, men too can suffer from dimpling of the skin, a condition known as "
peau d'orange" (skin of an orange).
Other important ocular findings include
peau d'orange, optic disc drusen, pattern dystrophy appearance, comet lesions and choroidal neovascularization.
La peau du sein peut devenir capitonnee (et prendre l'aspect d'une
peau d'orange) ou plissee.
reported worsening muscular tightness in the lower extremities, which progressed rapidly to rigid flexion contractures and a pronotmced tightening of the skin with
peau d'orange texture on the right hand and bilaterally in the legs.
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