pathogenicity island

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pathogenicity island (PAI)

a large gene cluster (‘island’), normally found on the CHROMOSOME of a pathogenic BACTERIUM, that specifies functions associated with VIRULENCE, for example production of TOXINS, ADHESINS. The cluster may be able to transpose to other REPLICONS, for example PLASMIDS, and be transferred in nature by HORIZONTAL GENE TRANSFER.
References in periodicals archive ?
A Novel Putative Enterococcal Pathogenicity Island Linked to the esp Virulence Gene of Enterococcus faecium and Associated with Epidemicity.
GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2.
These features suggest that this DNA fragment is a horizontally acquired transposon-like element (9) and together with the frequent association of the usp gene with UPEC strains, imply that this DNA fragment could be the previously unrecognized pathogenicity island (PAI) of UPEC.
Bacteriophage, pathogenicity islands and evolution of epidemic causing strains of V.
Constructing Salmonella enterica mutants for inactivating invG/invE y ssaJ/ssaK genes from pathogenicity islands 1 and 2
These virulent genes can be passed from one bacteria to another if the genome segments containing them, known as pathogenicity islands, are transferred from one to another.
The revised definition is based primarily on the presence of the LEE pathogenicity island, which is a marker of attaching-effacing capacity.
Two pathogenicity islands are required for full virulence of V cholera.
The GC content of this DNA differs from the core genome and the pathogenicity island appears to be integrated into redundant tRNA genes [16].
After ingestion of contaminated food/water, STEC colonizes enterocytes of the large bowel with a characteristic attaching and effacing pathology via components of type III secretion system (TTSS) encoded in the locus of enterocyte effacement (LEE) pathogenicity island.
Strain 229/11 also contains a 10-kb pathogenicity island (PAI) harboring the ratA, Sivl, and SivH genes and shares homology with PAI CS54 found in Salmonella spp.