Our finding of a small, but significant, increase of FLCs in MG may reflect the different
pathogenetic mechanism between organ specific and systemic autoimmune diseases like SLE and RA: in the latter conditions, FLCs can increase the inflammatory reaction, which is a relevant pathogenic aspect of these diseases [25] that is not present in an organ-specific autoimmune disease like MG.
The present case is unique because of the unprecedented origin of STM from pure seminoma generating one novel
pathogenetic hypothesis of STM.
Today, Curosurf remains the only drug for
pathogenetic therapy of RDS.
The
pathogenetic mechanisms leading to post-vaccination PR is unknown.
Correlation between clinical features of patients in conjunction with additional genomic analysis might provide further insight into the
pathogenetic determinants of this strain.
In this regard, the development of
pathogenetic therapy of chronic bacterial prostatitis that can influence the prostate inflammation pathogenesis and neutralize its negative impact on the sperm fertilizing capacity seems relevant.
Brown noted that 'A contentious question has been whether resistant hypertension is a
pathogenetic subset of hypertension, justifying a search for 'stratified medicines'; or is it an imaginary condition caused by doctors in white coats and patients who do not take their tablets?" said Dr.
Overall, bioinformatics tests suggest that the mutation is
pathogenetic. Exon 8 of the ACVRL1 gene carries 24% of the mutations identified in this gene in our lab.
Also related to ovarian teratomas, gliomatosis peritonei and its possible
pathogenetic mechanisms are discussed.
Even though the presence of autoantibodies in SLE has been known for more than 60 years, still nowadays a great effort is being made to understand the
pathogenetic, diagnostic, and prognostic meaning of such autoantibodies.
In fact, advances in our knowledge of AD have shown that symptoms usually develop after a long preclinical
pathogenetic process, making early detection of AD in asymptomatic subjects of great interest.
While some authors suggested categorizing segmental necrotizing lesion in subclass III or IV according to the proportion of the involved glomeruli, others insisted on emphasizing segmental necrotizing lesion as the defining feature of subclass III independent of the proportion of affected glomeruli and stressed the presence of a different
pathogenetic mechanism similar to nonimmune pathogenesis in systemic vasculitis [9].
