pathergy


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pathergy

 [path´er-je]
1. an abnormal reaction to an allergen, either a subnormal reaction or an excessive reaction.
2. a condition of being allergic to several antigens. adj., adj pather´gic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

path·er·gy

(path'ĕr-jē),
Obsolete term for those reactions resulting from a state of altered activity, both allergic (immune) and nonallergic.
[G. pathos, disease, + ergon, work]
Farlex Partner Medical Dictionary © Farlex 2012

pathergy

Dermatology
The development of a skin lesion similar or identical to the “index lesion” at a site of mechanical trauma—e.g., the development of sterile pustules of traumatised skin in patients with Behçet’s disease.
 
Medspeak, retired
An obsolete nonspecific term for either
(1) An altered immune response to an antigenic challenge, or
(2) The sum of all the reactions arising in or secondary to an altered physiologic "baseline".
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

path·er·gy

(path'ĕr-jē)
Those reactions resulting from a state of altered activity, both allergic (immune) and nonallergic.
[G. pathos, disease, + ergon, work]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

pathergy

The appearance of a papular or pustular lesion around a point on the skin at which a sterile substance was injected 24 to 48 hours before.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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References in periodicals archive ?
In agreement with earlier reports, the data from this study did not show any major differences between the early-onset and late-onset groups with regard to pathergy positivity and HLA-B51 status (17, 18), whereas a previous report uncovered a strong association between ocular manifestations and HLA-B51 positivity (19).
Clinical findings Number Percentage (n) (%) Oral aphthae 23 76.7 Genital ulcerations 13 43.3 Eye symptoms 16 53.3 Papulopustular eruptions and EN 18 60 Joint involvement (arthritis/arthralgia) 12 40 Vascular involvement (DVT/ 3 10 thrombophlebitis) Neurological involvement 3 10 Positive pathergy test 19 63
Multidisciplinary discussions are required when considering any debridement of necrotic tissue, skin grafting, or negative pressure dressings due to increased risks of pathergy and infection.
Each systemic finding (like the presence of oral ulcers, genital ulcers, cutaneous manifestations, a positive pathergy test, systemic vasculitis, CNS manifestations, arthralgia, arthritis, and/or gastrointestinal tract (GIT) symptoms) was also recorded if present for each participating patient.
Meanwhile, 48.7% of the patients fulfilling the ISG criteria had eye manifestations, 21.1% had a positive pathergy test/reaction, and 17.1% had venous thrombosis.
The patognomic symptoms are recurrent oral aphtae accompanies with at least two of these; positive pathergy test, skin lesions, recurrent genital ulcers and lesions in the eye.
Pathergy test was performed for all patients by dermatologists and evaluated at 24 and 48 hours.
The pathergy skin test result was positive, and she was diagnosed with BD.
Certain regional/geographical differences may exist; for example, pathergy phenomenon and ocular lesions are less commonly seen in the West [31-33], while gastrointestinal manifestations are more commonly seen in the Far East [34].
According to the International Study Group for BD criteria, the presence of any two of the following symptoms, in addition to recurrent oral ulcerations, is considered to be sufficient for a BD diagnosis: recurrent genital ulceration, uveitis, large-vessel vasculitis, cutaneous erythema nodosum, arthritis, and/or a positive pathergy test.
Although the disease rates and the clinical expression vary to some extent by ethnic origin, recurrent mucocutaneous lesions, skin lesions, ocular findings, and reactivity of the skin to needle prick or injection (pathergy test) constitute the most common clinical hallmarks of BD.
Clinical features Total % Patients with BD 371 Mean age [+ or -] SD 33.2 [+ or -] 8.4 Male 326 87.9 Female 45 12.1 Uveitis 358 96.5 Oral ulcer 349 94 Genital ulcer 208 56.1 Skin lesion 272 73.3 Arthritis 53 14.3 Pathergy reaction 8 2.2 Patients with VKH disease 371 Mean age [+ or -] SD 39.8 [+ or -] 13.9 Male 204 55 Female 167 45 Sunset glow fundus 182 49 Headache 157 42.3 Tinnitus 146 39.4 Vitiligo 123 33.2 Alopecia 136 36.7 Gray hair 58 15.6 Controls 605 Mean age [+ or -] SD 38.6 [+ or -] 11.1 Male 321 53.1 Female 284 46.9 BD = Behcet's disease, SD = standard deviation; VKH = Vogt-Koyanagi- Harada.