paternal age effect


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paternal age effect

The effect that increased paternal age has on the incidence of genetic disease.

Conditions with paternal age effect
Achondroplasia, acrodysplasia, Klinefelter syndrome, Marfan syndrome. Paternal chromosomal defects occur in 2.6% of habitual abortions; most are translocations, occurring at a rate of 10-fold greater than normal. Increased maternal age is classically associated with chromosome defects in progeny, often in trisomies.
References in periodicals archive ?
Paternal age effect is more prominent with point mutation than with deletions as point mutations are almost entirely from sperm, whereas the deletions are derived from both parents.
After evaluating 158 cases of prenatally diagnosed trisomy, (21) including 60 from the Federal Republic of Germany 8 and 98 from the New York State chromosome registry, Stene et al described a paternal age effect (stene et al 1987).
We defined the parental age effect on Down's syndrome and clarified whether a paternal age effect exists as a risk factor.
A search for evidence for a paternal age effect independent of a maternal age effect in birth certificate reports of Down's syndrome in New York State.
The paternal age effect in Apert Syndrome is due, in part, to the increased frequency of mutations in sperm.
These hypothesized mechanisms for paternal age effects on risk of ASD are genetic.