paternal age effect
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paternal age effectThe effect that increased paternal age has on the incidence of genetic disease.
Conditions with paternal age effect
Achondroplasia, acrodysplasia, Klinefelter syndrome, Marfan syndrome. Paternal chromosomal defects occur in 2.6% of habitual abortions; most are translocations, occurring at a rate of 10-fold greater than normal. Increased maternal age is classically associated with chromosome defects in progeny, often in trisomies.
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