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agglutination of particles that have been coated with soluble antigen, by antiserum specific for the adsorbed antigen.
Synonym(s): indirect agglutination
A test for the presence of a specific antibody in which inert particles or cells with no foreign antigenic markers are coated with a known soluble antigen and mixed with serum. If clumping occurs, the patient's blood contains antibodies specific to the antigen. In the past, red blood cells were used as the carriers after they were washed to remove any known antibodies; currently, latex, bentonite, and charcoal also are used.
See also: agglutination