parthenolide


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parthenolide

Pharmacognosy
A natural sesquiterpene lactone found in feverfew (Tanacetum parthenium), which has a variety of in vitro activities:
• Inhibition of serotonin and prostaglandins, which may explain feverfew’s efficacy in treating migraines; 
• Induces apoptosis, killing the stem cells that give rise to acute myeloid leukaemia;
• Blocks Leishmania amazonensis;
• Interferes with microtubule activity;
• Anti-inflamatory; and
• Analgesic.
References in periodicals archive ?
It's thought the herb's active compound - parthenolide - helps relieve muscle spasms.
10 LC1 (Leuchemix): Orally-bioavailable Parthenolide Analogue
10) It is relevant to note that a purified feverfew extract free of parthenolide must be used in topical preparations to avoid phototoxic or photo-allergic reactions.
Our study revealed that parthenolide is not one of the major anti HSV-1 principles of tansy, as has been suggested.
Y cynhwysion gweithredol yn y wermod wen ydi parthenolide a tanetin.
However, little research has been done to investigate the antimicrobial activities of parthenolide and feverfew extracts against such food pathogens as L.
Its leaves contain a chemical called parthenolide that seems to reduce headaches.
Its main active ingredient, parthenolide, has been shown to inhibit prostaglandin synthetase and cyclooxygenase activity in leukocytes.
Of this group, the most important is parthenolide, which is critical for therapeutic interventions.
Look for a product with a standardised parthenolide content as this is thought to be the primary active component.