parthenolide

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parthenolide

Pharmacognosy
A natural sesquiterpene lactone found in feverfew (Tanacetum parthenium), which has a variety of in vitro activities:
• Inhibition of serotonin and prostaglandins, which may explain feverfew’s efficacy in treating migraines;
• Induces apoptosis, killing the stem cells that give rise to acute myeloid leukaemia;
• Blocks Leishmania amazonensis;
• Interferes with microtubule activity;
• Anti-inflamatory; and
• Analgesic.

References in periodicals archive ?

Feverfew contains parthenolide, which potently inhibits NF-kB, which trigger migraines, while willow bark contains a chemical similar to aspirin (salicin).

4 Natural Ways To Get Rid Of A Migraine

The control of experimental canine Pseudomonas aeruginosa infection was optimised via a combined therapy including enrofloxacin against the bacteria and parthenolide (active component of the plant Tanacetum parthenium) for correction of inflammatory reaction.

EFFECTS OF FEVERFEW (TANACETUM PARTHENIUM) AND ANTIBIOTIC CO-ADMINISTRATION ON BLOOD NEUTROPHIL FUNCTION AND SERUM PROCALCITONIN IN DOGS WITH EXPERIMENTAL SUBCUTANEOUS PSEUDOMONAS AERUGINOSA INFECTION

Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).

How vegetable extracts protect against cancer

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.

I?B kinase b Mediating the Downregulation of p53 and p21 by Lipopolysaccharide in Human Papillomavirus 16[sup]+ Cervical Cancer Cells

Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.

Cardiovascular aspects of geriatric medicines in traditional Persian medicine; a review of phytochemistry and pharmacology

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide.

Anticancer activity of eugenol is not related to regulation of the oncogenic transcription factor Forkhead Box M1/Atividade anticarcinogenica do eugenol nao se deve a modulacao do fator de transcricao oncogenico Forkhead Box M1

Trypanosoma cruzi: Antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.

Investigating a number of Iranian herbal medicine, in the form of capsule regarding the product components, active ingredients, pharmacological effects and antimicrobial properties

Zhu, "A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells," Pancreas, vol.

Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer

Its active constituent parthenolide inhibits platelets aggregation via inhibition of serotonin release with no bleeding side effect recorded.

Drug interaction and its implication in clinical practice and personalized medicine

Recently, the interaction between benznidazole and parthenolide was investigated against T.

Toxicity and loss of mitochondrial membrane potential induced by alkyl gallates in trypanosoma cruzi

Parthenolide comprises up to 85% of the total sesquiterpene content and is found primarily in the superficial leaf glands (0.

Select nutritional components to support migra ine heada ches

Radio-sensitization of the murine osteosarcoma cell line LM8 with parthenolide a natural inhibitor of NF-kappaB.

Relationship between TLR4 and NF-B p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma