parthenolide


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parthenolide

Pharmacognosy
A natural sesquiterpene lactone found in feverfew (Tanacetum parthenium), which has a variety of in vitro activities:
• Inhibition of serotonin and prostaglandins, which may explain feverfew’s efficacy in treating migraines; 
• Induces apoptosis, killing the stem cells that give rise to acute myeloid leukaemia;
• Blocks Leishmania amazonensis;
• Interferes with microtubule activity;
• Anti-inflamatory; and
• Analgesic.
References in periodicals archive ?
Feverfew contains parthenolide, which potently inhibits NF-kB, which trigger migraines, while willow bark contains a chemical similar to aspirin (salicin).
The control of experimental canine Pseudomonas aeruginosa infection was optimised via a combined therapy including enrofloxacin against the bacteria and parthenolide (active component of the plant Tanacetum parthenium) for correction of inflammatory reaction.
Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.
Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.
Zhu, "A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells," Pancreas, vol.
Its active constituent parthenolide inhibits platelets aggregation via inhibition of serotonin release with no bleeding side effect recorded.
Recently, the interaction between benznidazole and parthenolide was investigated against T.
Parthenolide comprises up to 85% of the total sesquiterpene content and is found primarily in the superficial leaf glands (0.
Radio-sensitization of the murine osteosarcoma cell line LM8 with parthenolide a natural inhibitor of NF-kappaB.