parthenolide

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parthenolide

Pharmacognosy
A natural sesquiterpene lactone found in feverfew (Tanacetum parthenium), which has a variety of in vitro activities:
• Inhibition of serotonin and prostaglandins, which may explain feverfew’s efficacy in treating migraines;
• Induces apoptosis, killing the stem cells that give rise to acute myeloid leukaemia;
• Blocks Leishmania amazonensis;
• Interferes with microtubule activity;
• Anti-inflamatory; and
• Analgesic.

References in periodicals archive ?

"We were interested in finding out more about the potential of parthenolide. With expertise from colleagues in the School of Chemistry we've been able to demonstrate that this compound shows real promise."

Flower found to kill cancer cells

"It's a clear demonstration that parthenolide has the potential to progress from the flower bed into the clinic."

Flower power could destroy cancer cells; BRUM BOFFINS DISCOVER POTENTIAL NEW DRUG

Researchers said the parthenolide compound, found in its leaves, could be key to cancer treatments after it was modified to attack tumours.

FLOWER POWER COULD KILL CANCER CELLS

Prof John Fossey said: "This is important because we have shown a way of producing parthenolide that could make it much more accessible and also because we've been able to improve its 'drug-like' properties to kill cancer cells.

Flower power 'kills cancer' Scientists discover common garden plant can destroy leukaemia cells

The compound the Birmingham team were investigating is called parthenolide and was identified by scientists as having anti-cancer properties several years ago.

The University of Birmingham: Hidden chemistry in flowers shown to kill cancer cells

Parthenolide sensitizes hepatocellular carcinoma cells to trail by inducing the expression of death receptors through inhibition of JAK2/STAT3 activation J Cell Physiol.

OncANP 2019

Hepato-protective effect of parthenolide in rat model of nonalcoholic fatty liver disease.

Hepatoprotective Effects of Silymarin on Liver Injury via Irisin Upregulation and Oxidative Stress Reduction in Rats with Type 2 Diabetes

This activity arises from a compound, parthenolide, which produces a similar effect to cortisone.

Plant of the week: Plant long known for action against migraine

(67) The prominent active constituents of feverfew are sesquiterpene lactones, namely parthenolide, which possesses antisecretory, anti-inflammatory, and antispasmodic actions.

The potential of herbal medicine in the management of endometriosis

Fu et al., "Parthenolide ameliorates concanavalin A-induced acute hepatitis in mice and modulates the macrophages to an anti-inflammatory state," International Immunopharmacology, vol.

Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy

PEG-PE micelles prepared from conjugates of polyethylene glycol (PEG) and phosphatidylethanolamine (PE) have a core-shell structure which can encapsulate hydrophobic drugs such as paclitaxel, parthenolide, tamoxifen, campotheicin, and budesonide [11].

Polymer-Stabilized Micelles Reduce the Drug Rapid Clearance In Vivo

Haloperidol, chlorpromazine, MG-132, pyrrolidine dithiocarbamate (PDTC), aprotinin, phenylmethylsulfonyl fluoride (PMSF), [beta]-mercaptoethanol, brilliant blue G-colloidal concentrate, Brij 35 solution, diethyl pyrocarbonate (DEPC), dithiothreitol (DTT), N-(2-hydroxyethyl)piperazine-N -(2-ethanesulfonic acid) (HEPES), leupeptin, lipopolysaccharide (LPS; Escherichia coli, serotype 0127: B8), parthenolide, and 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) were purchased from Sigma-Aldrich (St.

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-[kappa]B Activation in Stimulated Human Monocytic Cells