parthanatos

parthanatos

A molecular biology term for caspase-independent fragmentation of chromosomal DNA.
References in periodicals archive ?
Liu et al., "Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy," Cellular and Molecular Neurobiology, vol.
Effect of parthanatos on ropivacaine-induced damage in SH-SY5Y cells.
The scope of regulated necrosis has evolved rapidly to include not only necroptosis but also ferroptosis, oxytosis, parthanatos, and pyroptosis and others [5].
Our findings also show that regulated death at an acidic pH relies not only on the function of RIPK1, caspase-8, but also PARP-1, implicating parthanatos [41] as well as apoptosis and necroptosis.
Poly(ADP-ribosyl)ation was activated under critical situations with oxidative-nitrative stress-induced DNA damage and was shown to play a regulatory role in different cell death pathways, such as apoptosis, autophagy, necroptosis, and parthanatos [6].
This crosstalk between nucleus and mitochondria is the key point in special cell death pathway called parthanatos [8].
The predilection for caspase-independent cell death in males, as in PARP-1 inhibition, may be due to decreased antioxidant defenses and increased susceptibility to ROS and peroxynitrite production, stimulating both mitophagy and parthanatos [30].
A variety of other, non-apoptotic mechanisms have been proposed to contribute to retinal cell death (Arango-Gonzalez et al., 2014), including autophagy and parthanatos (Punzo et al., 2009; Feenstra et al., 2013; Arango-Gonzalez et al., 2014).
Of note, the DNA repairing enzyme PARP-1, which is also recognized as an apoptotic marker, has been recently shown to be central in a genuine type of cell death termed parthanatos [55], and its potential role in DCM has already been stated [56].
The team noted that Iduna works by interrupting a cascade of molecular events that result in a common and widespread type of brain cell death called parthanatos often found in cases of stroke, Parkinson's Disease, diabetes and heart attack.
PARP was also reported to induce caspase independent cell death called parthanatos [50-52].