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a broad-spectrum antibiotic derived from Streptomyces rimosus var. paromomycinus; the sulfate salt is used as an antiamebic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Pregnancy Category: C
Treatment of acute and chronic intestinal amebiasis.Management of hepatic coma as adjunctive therapy.
Inhibits protein synthesis in bacteria at level of 30S ribosome.
Resolution of amebic infections.Notable for activity against:
- Entamoeba histolytica,
- Dientamoeba fragilis,
- Diphyllobothrium latum,
- Taenia saginata,
- Giardia lamblia.
Absorption: Minimal to no systemic absorption.
Metabolism and Excretion: 100% excreted in feces.
Contraindicated in: Hypersensitivity to paromomycin or other aminoglycosides; Intestinal obstruction.
Use Cautiously in: Renal impairment; Ulcerative bowel lesions; Obstetric / Lactation / Pediatric: Safety not established.
Adverse Reactions/Side Effects
- abdominal cramps
- hypersensitivity reactions
InteractionsInteractions are listed for systemically absorbed drug
Drug-Drug interactionMay enhance possible respiratory paralysis after inhalation anesthetics or neuromuscular blockers.↑ risk of ototoxicity with loop diuretics.May ↑ the anticoagulant effects of warfarin.May ↓ the absorption of digoxin and methotrexate.
Oral (Adults and Children) 8.33–11.67 mg/kg 3 times daily with meals for 5–10 days.
Oral (Adults) 4 g/day in 2–4 divided doses for 5–6 days.
Availability (generic available)
Capsules: 250 mg
- Assess patient for infection (vital signs, stool) at beginning of and periodically throughout therapy.
- Hepatic Coma: Monitor neurologic status. Prior to administering oral medication, assess patient's ability to swallow.
Potential Nursing DiagnosesRisk for infection (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)
- Keep patient well hydrated (1500–2000 mL/day) during therapy.
- Oral: Administer with meals.
- Instruct patient to take as directed for full course of therapy. Missed doses should be taken as soon as possible if not almost time for next dose; do not double doses.
- Advise patient of the importance of drinking plenty of liquids.
- Caution patient that medication may cause nausea, vomiting, or diarrhea.
- Advise patient to notify health care professional if ringing in the ears, hearing impairment, or dizziness occurs.
- Resolution of amebic infection.
- Improved neurologic status in hepatic coma.
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