Clinical symptoms in early stage AD patients occur with involvement of the limbic structures and parietotemporal
The cerebral pattern of this deposition was similar to that seen in patients with other forms of AD, primarily affecting the posterior cingulate, precuneus, parietotemporal
, frontal, and basal ganglial regions, the researchers said (Lancet Neurol.
66) A similar study, conducted on twenty-nine different primate taxa, including twenty prosimians, eight Old World monkeys, and humans, again demonstrated large relative increases in gyrification in prefrontal cortical regions and in parietotemporal
association cortical regions in humans (Figure 2).
Patients with AD demonstrate a pattern of hypometabolism most prominent in the parietotemporal
cortex and posterior cingulate cortex, and the pattern is more often symmetric though it can be asymmetric.
Carnegie Mellon researchers say poor readers initially have less activation in the parietotemporal area of the brain, which is the region responsible for decoding the sounds of written language and assembling them into words and phrases that make up a sentence, than do good readers.
Using functional magnetic resonance imaging (fMRI), CCBI Research Fellows Ann Meyler and Tim Keller measured blood flow to all of the different parts of the brain while children were reading and found that that the parietotemporal areas were significantly less activated among the poor readers than in the control group.
Marie examined Tans brain and argued that the lesion was not limited to the frontal lobe, but also involved the parietotemporal