The formulation of PPIs ensures that, following absorption into the plasma, they accumulate in the gastric parietal cells
. This means they do not affect other proton pumps in tissues elsewhere in the body.
To achieve the same effect all PPIs are marketed in delayed-release enteric-coated form so that they do not get activated by acid in the stomach but they dissolve in the intestine from where the drugs take a detour through general circulation and appear at the doorstep of H+/K+ ATPase pumps located on parietal cells
of gastric mucosa.
PA is macrocytic anemia due to vitamin B12 deficiency as a result of deficiency of intrinsic factor because of the atrophy of gastric mucosa and thus the loss of parietal cells
.9 Varying incidence rates of PA have been reported.1011
These results suggested that they did not block the [H.sub.2] receptors at gastric parietal cells
or influence the intracellular mechanisms involved with histamine activity.
The vitamin then forms a complex with intrinsic factor, a specific glycoprotein that is secreted postprandially by parietal cells
in the gastric lining, and moves toward the ileum to attach to receptors on the terminal ileum membrane.
Following the earlier literature and current conventions, Dahlgren and Clifford (1982) identified two characters relating to the micropylar region of the nucellus in monocotyledons: (1) presence or absence of parietal cell
(sometimes called "tapetal cell," or Deckzellen) and (2) presence or absence of a multiseriate nucellar cap derived from cell divisions in the nucellar epidermis.
Esopha-geal stenosis at the cervico-thoracic junction, gastric lamina propria fibrosis, atrophic gastritis, parietal cell
dropouts, and esophageal intraepithelial lymphocytosis were extremely common, whereas recurrent enteropathy and enterocolitis with striking villous atrophy, extensive apoptosis, and anaphase bridging pointing toward regenerating defect were very commonly reported in the lower GI tract.
antibodies among Peruvians with gastric pathology.
* PARIETAL CELL
VAGOTOMY: for unresectable Gastrinomas.
Archesporium produces a parietal cell
and a primary sporogenous cell.
During follow-up, all autoimmune serologic tests--including tests for anti-smooth-muscle antibodies, antimitochondrial antibodies, gastric parietal cell
antibodies, rheumatoid factor, anti-Rho, anti-La, SS-A, SS-B, RNP, and antinuclear antibodies--were negative.
Histamine stimulates gastric acid secretion by direct interaction at the parietal cell
[H.sub.2]-receptors that are coupled to the adenylyl cyclase system through G proteins.