Evaluating the parent-of-origin effect in bipolar affective disorder Is a more penetrant subtype transmitted paternally?
Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder J Affect Disord 1998; 50:135-141.
We've known that there are 95 genes that are subject to this parent-of-origin effect.
Studying them in genetically diverse mouse models that take parent-of-origin into account will give scientists more precise insights into the underlying causes of disease and the creation of therapeutics or other interventions.
POD QTL were tested with a series of tests to differentiate parent-of-origin effects (complete imprinting) from Mendelian effects.
Our simulation results strongly suggest that POD QTL be tested with the presented tests (2 and 3) to differentiate POD expression from parent-of-origin expression (complete imprinting).
specific gene expression involves silencing of one of the copies of the gene.
The next three chapters present a detailed review of the molecular and statistical aspects of imprinted genes and parent-of-origin
effects on production traits.
2007) performed genome scans to detect Mendelian and parent-of-origin QTL for growth and body composition traits in a cross population of KNP and Landrace.
For each chromosome, least squares interval mapping models were applied to detect Mendelian and parent-of-origin QTL.
QTL models with parent-of-origin
effect have been implemented to identify genes that have gene expression patterns in non-Mendelian patterns.