"It is tempting to overemphasise the role of a small number of parent-of-origin
expressing genes and to speculate about the effects of modest variation in methylation, but we must not be too hasty to blame either parent for their offspring's health outcomes without being certain that these effects are consequentially robust," the author wrote further.
To monitor fertility in 8-week-old mice and assessing parent-of-origin
effects, Paternal HT-P and Maternal HT-M mice were engendered by mating KO male with WT female and WT male with KO female, respectively.
Evaluating the parent-of-origin effect in bipolar affective disorder Is a more penetrant subtype transmitted paternally?
Failure to demonstrate parent-of-origin effect in transmission of bipolar II disorder J Affect Disord 1998; 50:135-141.
"We've known that there are 95 genes that are subject to this parent-of-origin effect.
Studying them in genetically diverse mouse models that take parent-of-origin into account will give scientists more precise insights into the underlying causes of disease and the creation of therapeutics or other interventions.
POD QTL were tested with a series of tests to differentiate parent-of-origin effects (complete imprinting) from Mendelian effects.
Our simulation results strongly suggest that POD QTL be tested with the presented tests (2 and 3) to differentiate POD expression from parent-of-origin expression (complete imprinting).
specific gene expression involves silencing of one of the copies of the gene.
The next three chapters present a detailed review of the molecular and statistical aspects of imprinted genes and parent-of-origin
effects on production traits.
(2007) performed genome scans to detect Mendelian and parent-of-origin
QTL for growth and body composition traits in a cross population of KNP and Landrace.
QTL models with parent-of-origin
effect have been implemented to identify genes that have gene expression patterns in non-Mendelian patterns.