parecoxib


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parecoxib

A pro-drug of the cyclo-oxygenase-2 (COX-2) inhibitor VALDECOXIB and is used to relieve post-operative pain. A brand name is Dynastat.
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Thirty minutes prior to PAE, they received an intravenous dose of antibiotic (ceforadine, Radacef, 2 g), analgesic (parecoxib, Dynastat, 40 mg) and gastroprotective agent (ranitidine, Zantac, 50 mg).
The effects of intravenous paracetamol on postoperative pain have been previously studied in different surgeries and also evaluated and demonstrated opioid-sparing effects.16,19 Broadner et al.19 showed that the analgesic efficacy of paracetamol is not different from the efficacy of dipyrone and parecoxib when used to provide postoperative analgesia after various surgical procedures.
Postoperative analgesia consisted of administration of Parecoxib Na 40 mg intravenously (i.v.) every 6-8 h.
A meta-analysis of 114 trials comparing COX-2 selective inhibitors (rofecoxib, celecoxib, valdecoxib, parecoxib, etoricoxib, and lumiracoxib), conducted before June 2006, revealed significant heterogeneity in renal events (renal dysfunction, hypertension, and peripheral edema) between medicines in the class (p = 0.02), which was driven by rofecoxib [68].
(4) investigated the effects of a nonsteroid anti-inflammatory drug (parecoxib) on cognitive impairments and they concluded that parecoxib attenuated the nugatory effects induced by sevoflurane in rats.
The efficacy of the non-opioid analgesics parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdiscectomy.
[13] demonstrated that the COX-2 inhibitor parecoxib was able to inhibit CGRP release from cultured trigeminal ganglia cells, while in our study, the selective COX-2 inhibitor etoricoxib was not effective.
In both groups, after intracutaneous injections, an intramuscular injection of parecoxib sodium (40 mg; Pharmacia & Upjohn Company, USA) was administered intramuscularly in the gluteal region, if needed for additional treatment.
Contract awarded for Parecoxib sodium 20 mg / ml im, iv, 2 ml vial.
Celecoxib, roficoxib, parecoxib, and valdecoxib are among the members of this class.