parathyroid hormone-related peptide

parathyroid hormone-related peptide (PTHrP),

a hormone that can be produced by tumors, especially of the squamous cell type; massive overproduction can lead to hypercalcemia and other manifestations of hyperparathyroidism. PTHrP exerts a biologic action similar to that of parathyroid hormone (PTH), acting through the same receptor, which is expressed in many tissues but most abundantly in kidney, bone, and growth plate cartilage. It apparently has significant actions during development, but it remains uncertain whether PTHrP circulates at all or has any function in normal human adults. The structure of the gene for human PTHrP is more complex than that of PTH, and varying molecular forms exist, including proteins of 141, 139, and 173 amino acids, which share a significant homology with parathyroid hormone.

par·a·thy·roid hor·mone-re·lated pep·tide

(PTHrP) (par'ă-thī'royd hōr'mōn-rĕ-lā'tĕd pep'tīd)
A hormone that can be produced by tumors, especially of the squamous cell type; massive overproduction can lead to hypercalcemia and other manifestations of hyperparathyroidism. PTHrP exerts a biologic action similar to that of parathyroid hormone (PTH), acting through the same receptor, which is expressed in many tissues but most abundantly in kidney, bone, and growth plate cartilage. It apparently has significant actions during development, but it is uncertain whether PTHrP circulates at all or has any function in normal human adults. The structure of the gene for human PTHrP is more complex than that of PTH, and varying molecular forms exist, including proteins of 141, 139, and 173 amino acids, which share a significant homology with parathyroid hormone.
Compare: bioregulator
References in periodicals archive ?
Specifically, the production of prostaglandins, parathyroid hormone, parathyroid hormone-related peptide, activated vitamin D, IL-6, and TNF by cancer cells may lead to tumor-induced increases in RANKL expression on osteoblasts and bone marrow stromal cells [7].
Traditionally, humoral hypercalcemia of malignancy is referred to the over production of parathyroid hormone-related peptide (PTHrP).
Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
22-Oxacalcitriol, a noncalcemic analogue of calcitriol, suppresses both cell proliferation and parathyroid hormone-related peptide gene expression in human T cell lymphotrophic virus, type I-infected T cells.
Autocrine/paracrine involvement of parathyroid hormone-related peptide in vascular leiomyoma.
A parathyroid hormone-related peptide level >1.0 pmol/L is highly specific for malignancy
Expression and action of parathyroid hormone-related peptide in human cervical epithelial ceils.
Their topics in the fundamental concepts include an overview by the editors, and studies of parathyroid hormone-related peptide and malignancy.
This may reflect a true phenomenon because lead exposure has been reported to accelerate bony maturation by inhibiting the effects of parathyroid hormone-related peptide. Accelerated maturation of bone may ultimately result in a lower peak BMD being achieved in young adulthood, thus predisposing to osteoporosis in later life.
Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance.
It's called parathyroid hormone-related peptide, or PTHrP.

Full browser ?