paraprotein


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paraprotein

 [par″ah-pro´tēn]
a normal or abnormal plasma protein appearing in large quantities as a result of some pathologic condition, now replaced in most contexts by the term m component.

par·a·pro·tein

(par'ă-prō'tēn),
1. A monoclonal immunoglobulin of blood plasma, observed electrophoretically as an intense band in γ, β, or α regions, due to an isolated increase in a single immunoglobulin type as a result of a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. The finding of a paraprotein in a patient's serum indicates the presence of a proliferating clone of immunoglobulin-producing cells and may be seen in a variety of malignant, benign, or nonneoplastic diseases.
2. Synonym(s): monoclonal immunoglobulin
[para + protein, fr. G. protos, first]

paraprotein

/para·pro·tein/ (-pro´tēn) a normal or abnormal plasma protein appearing in large quantities as a result of a pathological condition; term now largely replaced by M component.

paraprotein

[-prō′tēn]
any of the incomplete monoclonal immunoglobulins that occur in plasma cell disorders.

M spike

A term of art referring to a zone of increased concentration of a monoclonal immunoglobulin when seen by serum electrophoresis.

par·a·pro·tein

(par'ă-prō'tēn)
1. A monoclonal immunoglobulin of the blood plasma, produced by a clone of plasma cells arising from the abnormal rapid multiplication of a single cell. Paraprotein in serum may be seen in various malignant, benign, or nonneoplastic diseases.
2. Synonym(s): monoclonal immunoglobulin.
[para + protein, fr. G. protos, first]

paraprotein

An abnormal plasma protein such as the MONOCLONAL immunoglobulin in MYELOMATOSIS.

Paraprotein

M-protein; abnormal immunoglobulin produced in multiple myeloma.
Mentioned in: Multiple Myeloma

paraprotein

immunoglobulin produced by a clone of neoplastic plasma cells proliferating abnormally, e.g. myeloma proteins and cryoglobulins. See also monoclonal gammopathy.
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References in periodicals archive ?
Laboratory studies show an abnormal paraprotein in 90% of cases.
Generalized asymptomatic skin coloured papular eruption
16] only seven out of 10 HIV-positive MM patients showed paraproteins of the IgG type and three patients were found to have an IgA paraprotein, K-light chain disease or non-secretory myeloma.
Concomitant HIV infection in newly diagnosed multiple myeloma patients is hard to recognise and should be tested for routinely in areas of high endemicity
Patients with MF-MM had advanced myeloma bone disease (MBD), significantly lower clonal plasma cell infiltration in bone marrow, and lower paraprotein level.
MULTIPLE MYELOMA WITH ADVANCED BONE DISEASE AND LOW TUMOR BURDEN--DIFFERENT CLINICAL PRESENTATION BUT SIMILAR OUTCOME AFTER BORTEZOMIB-BASED THERAPY AND RADIOTHERAPY
Under these circumstances, a free double-membrane vesicle, derived from a mitochondrion or the rough endoplasmic reticulum, encapsulates cytoplasmic materials such as paraprotein, cellular metabolites, or injured organelles, to form autophagosomes.
Correlation between Cholinergic Innervation, Autophagy, and Etiopathology of Benign Prostatic Hyperplasia
The NZIMLS best presenter was awarded to Claudia Sugrue, for her presentation on an IgE paraprotein and the runner up best presenter was awarded to Maria Carter for her presentation on Beer Potomania.
Biochemistry Special Interest Group
In patients with immune complex type MPGN, the paraprotein likely forms part of the immune complex causing activation of the classic complement pathway and resulting in renal injury with both abnormal immunoglobulin and complement on immunohistochemistry.
C3 glomerulonephritis and plasma cell dyscrasia: expanding the etiologic spectrum
MGUS is a condition resembling multiple myeloma in which a paraprotein is found in the blood.
Mesenteric plasmacytoma: An unusual cause of an abdominal mass
His serum immunoglobulins were normal and no serum paraprotein was detected.
Multiple myeloma related amyloidosis: a rare neurological manifestation
Ancak izole paraprotein ile fibroblast proliferasyonu saglanamamistir (5).
A case of scleromyxedema without monoclonal gammopathy responded to treatment with IVIG/IVIG tedavisine yanit veren bir monoclonal gamopatisiz skleromiksodem olgusu
Serum protein electrophoresis did not reveal the presence of a paraprotein.
Primary localized laryngeal amyloidosis presenting with dysphonia: a case report
Key facts about disease MYELOMA is a blood cancer where malignant plasma cells in the bone marrow produce paraprotein - an abnormal antibody which can't fight infection.
My cancer's so rare, I hadn't even heard of it... But I'm not going to let it ruin my life
The factors that predispose to Auer rod-like inclusions in myeloma are unknown; however, in all reported cases paraprotein was of the kappa type.
Myeloma cells with Auer rod-like inclusions / Auer Cubugu Benzeri Inkluzyonlara Sahip Myeloma Hucreleri

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