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Features such as renal dysfunction, a significant paraprotein, osteolytic lesions, hypercalcemia, and diffuse bone marrow involvement favor a diagnosis of plasmablastic plasma cell myeloma.
A decreased anion gap (1-3 mEq/L) is consistent with elevated protein as seen in some malignancies, especially with a monoclonal paraprotein (multiple myeloma).
Serologic data regarding monoclonal paraprotein for this cohort was available in 40 LPL cases (89%).
Paraprotein interference in automated chemistry analyzers.
Lymphoplasmacytic lymphoma is a mature B-cell lymphoma with plasmacytoid appearance and differentiation and is mostly associated with paraprotein of immunoglobulin M type.
Aside from the standard laboratory testing, identification of monoclonal Ig (paraprotein) by serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE) are the current gold standards supported by the International Myeloma Working Group (IMWG) for diagnosis and monitoring therapy (2).
(49) However, marginal zone lymphomas and other B-cell lymphoproliferative disorders may be associated with an IgM paraprotein, so this finding alone is not fully discriminatory.
A Monoclonal gammopathy of undetermined significance (MGUS) is the term used to denote the presence of a monoclonal protein (M-protein, myeloma protein, or paraprotein) in persons without evidence of plasma-cell myeloma, Waldenstrom macroglobulinemia, primary amyloidosis, or related disorders.
Artifactual hyperbilirubinemia due to paraprotein interference.
(76) Flow cytometry is applicable to virtually all patients, and it is more sensitive than paraprotein or light-chain assessment.
Multiple myeloma is a hematologic malignancy characterized by proliferation of a neoplastic plasma cell population that usually leads to abundant production of a monoclonal immunoglobulin, also called paraprotein or M-protein, as well as decreased concentrations of normal polyclonal immunoglobulins.
Nevertheless, we suggest the following: perhaps, the amount of paraprotein in the serum or urine was pathologic, but less than the limits of detection.