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An organophosphorus cholinesterase inhibitor used in insecticides; parathion is converted in the liver to paraoxon.
References in periodicals archive ?
At an absorbance of 412 nm at 37AoC the percentage of paraoxon hydrolysis (diethyl-p-nitrophenyl phosphate) was measured.
An example of this phenomenon is paraoxon, the active metabolite of the pesticide parathion, which is metabolized by enzymes with native lactonase activity (Khersonsky and Tawfik 2005).
Foi utilizado acido ditiobisnitrobenzoico (DTNB), iodeto de acetiltiocolina, iodeto de pralidoxima e paraoxon do fabricante Sigma- Aldrich[R] e foi utilizado o leitor de microplacas por espectroscopia do fabricante Molecular Devices[R], disponivel no laboratorio do Instituto de Biologia do Exercito.
Adverse outcome pathways during zebrafish embryogenesis: A case study with paraoxon.
1988) Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon.
PON1 activity was measured by spectrophotometric evaluation of 4-nitrophenol, which is the enyzmatic product of the substrate paraoxon (O, O-diethyl-Op-nitrophenyl phosphate; Sigma Co.
The Q alloenzyme is less efficient in hydrolyzing paraoxon but more efficient toward oxidized lipoproteins than the R alloenzyme [21].
The activities of paraoxonase (PON) and arylesterase (ARE) were estimated spectrophotometrically with the use of paraoxon and phenyl acetate as respective substrates according to previously described methods [24, 25].
Human serum paraoxonase/aryl esterase (PON 1), (2) is a calcium dependent enzyme that hydrolyses organophosphates such as paraoxon, diazoxon, sarin, and soman, and also arylesterases such as phenyl acetate.
The PONase activity was measured using paraoxon (Sigma Chem, USA) as substrate and the increase in absorbance at 412 nm was determined, because of 4 -nitrophenol formation.