Inset: these cells contained a large vesicular to hyperchromatic nucleus and an intracytoplasmic, paranuclear
, eosinophilic, globular inclusion-like body (arrow).
(14) Nuclear reactivity with Wilms tumor-1 (WT-1) is seen in most of the cases with only rare reports of cytoplasmic dotlike paranuclear
pattern positivity (Figure 2, D).
Histological appearance suggests small cell undifferentiated Merkel Cell carcinoma, confirmed through IHC with positive values of approximately 80% for Ki67, diffusely positive values for Synaptophysin, Chromogranin A and CK20 in tumor cells with a paranuclear
The spindle cell type which comprises of the majority of tumors has uniform pale eosinophilic cytoplasm, oval to short spindled nuclei, paranuclear
vacuoles and skeinoid fibers (fig-2).
CK-20 is a highly sensitive marker for MCC, staining positively in a paranuclear
, dot-like pattern in 89% to 100% of tumors .
IL-1-like protein immunostaining was paranuclear
. The intensity of immunostaining was more prominent in the hyperplasic ovary than in the normal ovary, indicating a greater prevalence of oocytes in the hyperplastic ovary (Fig.
(e) The RS-like B-cells are CD30positive with characteristic paranuclear
The cytoplasm was pale eosinophilic, granular, and occasionally contained hyaline rhabdoid paranuclear
inclusions (Figure 2(c)).
[DELTA]201 NcGRA9-HA, missing the PEST domain and a hydrophobic alpha helix, was never found in the vacuolar space but was detectable in the paranuclear
region of the intravacuolar tachyzoites.
These changes appeared as microscopic foci of multivesicular cytoplasmic vacuoles, commonly noted in the paranuclear
Cytoplasmic and membrane staining was noted for CEA, Typical paranuclear
membrane, or lateral cell border staining was assessed for Vimentin (6) and Nuclear staining for ER and PR.
In contrast to the NLRP3 inflammasome, ASC was constitutively expressed in unstimulated cells,[sup] and the accumulation of ASC specks were triggered to redistribute and form a paranuclear
protein speck in activated cells.