paraneoplastic syndrome


Also found in: Dictionary, Thesaurus, Financial, Encyclopedia, Wikipedia.

paraneoplastic syndrome

 [par″ah-ne″o-plas´tik]
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.
Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.
References in periodicals archive ?
Timely and accurate diagnosis and treatment of paraneoplastic syndromes can greatly affect patient's clinical outcomes.
Wang, "Refractory diarrhea: A paraneoplastic syndrome of neuroblastoma," World Journal of Gastroenterology, vol.
A case of paraneoplastic syndrome mimicking adult-onset Still's disease.
Nevertheless, the association of a neuroendocrine tumor with a paraneoplastic syndrome may contribute to marked disease morbidity.
Paraneoplastic syndromes may be associated with mood changes and other psychiatric symptoms.
A surgical operation may determine the route of depressive disorders, when they are caused by endocrine tumours or paraneoplastic syndromes.
The most frequent causes of spinal myoclonus are spinal cord compression, tumour, vascular myelopathy, infection, demyelinating disease, paraneoplastic syndrome and trauma.
Final diagnosis of 'Nephrotic Syndrome as a Paraneoplastic syndrome in a patient with Thymic mass' was made and planned for Thymectomy with excisional biopsy.
POEMS syndrome is a rare paraneoplastic syndrome driven by neoplastic plasma cells.
Stiff person syndrome (SPS) is a rare neuroimmunological disorder identified as an autoimmune or paraneoplastic syndrome [1].
In rare instances, aberrant hormone production by the tumor cells may result in a paraneoplastic syndrome. Outcome and management are different for each tumor type, but surgery is generally used for all, with chemotherapy added for the atypical carcinoid and small or large cell neuroendocrine carcinomas.
Thereby, the patient was finally diagnosed to have SVC syndrome due to thrombosis as a paraneoplastic syndrome in bronchogenic carcinoma.