paraneoplastic syndrome


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paraneoplastic syndrome

 [par″ah-ne″o-plas´tik]
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.
Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm)
Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.

paraneoplastic

auxiliary to neoplasia.

paraneoplastic syndrome
a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematological or neuromuscular disorders. See also pseudohyperparathyroidism.
References in periodicals archive ?
Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report.
Mood changes (typically depression), memory problems, paranoia, hypersomnolence, aggressive behavior, agitation, and catatonia have been associated with paraneoplastic syndromes.
But in spite of documented evidence of increased thrombosis and pulmonary embolism, a literature search came up with only a few case reports of SVC thrombosis due to paraneoplastic syndrome.
Tumour-induced osteomalacia (TIO) also known as oncogenic osteomalacia is a rare paraneoplastic syndrome usually presenting with bone pain recurrent fractures of long bones and muscle weakness generally in adults.
In the case of paraneoplastic syndromes, the severity of symptoms can be used as a guide to the response of tumor therapy, since treating the underlying tumor will often resolve the paraneoplastic features.
A novel antinuclear antibody associated with a lupus-like paraneoplastic syndrome.
Methods: Serum and cerebrospinal fluid (CSF) samples from patients referred to the program of encephalitis and paraneoplastic syndrome of Peking Union Medical College Hospital were tested with indirect immunofluorescence.
POEMS syndrome is a underlying plasma cell dyscrasia related paraneoplastic syndrome and CD is one of the major criteria in the diagnosis of this disease.
11) reported DM as a paraneoplastic syndrome that developed in a patient with uterine carcinosarcoma.
In addition, its presentation without bony metastasis as a part of paraneoplastic syndrome is recognised but uncommon.

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