paraneoplastic pemphigus


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paraneoplastic pemphigus

painful mucosal erosions and polymorphous skin eruptions with biopsy findings resembling pemphigus vulgaris, associated with neoplasm and serum antibodies reactive with intercellular substance of all epithelia; usually rapidly fatal.

par·a·ne·o·plas·tic pemph·i·gus

(par'ă-nē-ō-plas'tik pem'fi-gŭs)
Painful mucosal erosions and polymorphous skin eruptions with biopsy findings resembling pemphigus vulgaris, associated with neoplasm and serum antibodies reactive with intercellular substance of all epithelia; usually rapidly fatal.

paraneoplastic pemphigus

Pemphigus that arises together with or sometimes before malignancy, particularly B-cell lymphomas and chronic lymphocytic leukemia.
See also: pemphigus
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References in periodicals archive ?
Mediastinal follicular dendritic cell sarcoma with paraneoplastic pemphigus.
Paraneoplastic pemphigus associated with fatal bronchiolitis obliterans and intractable mucosal erosions: Treatment with cyclosporinin addition to steroid, rituximab immunoglobulin.
Castleman's tumours and production of autoantibody in paraneoplastic pemphigus.
Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus.
Rule out look-alike conditions, including erythema multiforme, sunburn, toxic shock syndrome, staphylococcal scalded skin syndrome, and paraneoplastic pemphigus.
This test is not specific for PV, however, because it can be provoked in other diseases such as paraneoplastic pemphigus, oral lichen planus, mucous membrane pemphigoid, epidermolysis bullosa, linear IgA disease, lupus erythematosus, dermatomyositis, chronic erythema multiforme, or graft versus-host disease (6).
Pemphigus vulgaris (PV) is one of a group of unique, related blistering disorders that includes pemphigus foliaceous (PF) and paraneoplastic pemphigus (PNP).
Immune dysfunction in the elderly encourages the development of several autoimmune disorders: bullous and benign mucous membrane pemphigoid, paraneoplastic pemphigus, and the potentially fatal pemphigus vulgaris.

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