paraneoplastic limbic encephalitis


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paraneoplastic limbic encephalitis

Abbreviation: PNLE
A brain disorder occurring in some patients with cancer, characterized by the rapid onset of memory loss, often with temporal lobe disease, seizures, delirium, or disturbances of mood. Patients with PNLE often have antibodies against tumor antigens that also react with nerve cell antigens. In some patients the neurological disorder improves after treatment of the responsible tumor.
See also: encephalitis
References in periodicals archive ?
Paraneoplastic limbic encephalitis (PNLE) was first described by Corsellis et al.
These two antibodies have in common the association with idiopathic or paraneoplastic limbic encephalitis [23, 24].
Patients with paraneoplastic limbic encephalitis commonly present with behavioral or mood changes that mimic those of psychiatric illnesses such as schizophrenia and bipolar disorder, which often delays diagnosis.