NF1-/-]) derived from dNFs, previously analyzed by MLPA, paralog
ratio analysis, and SNP array and found to bear a somatic NF1 deletion in each case [(20) and data not shown].
i) Characterize the biochemical and structural properties of RAD51 paralog
complexes ii) Define the interplay between BRCA2, PALB2, and the RAD51 paralogs
in forming pre-recombination complexes for RAD51 assembly, using biochemical approaches and electron microscopic visualisation.
Exhaustive experiments have been conducted to characterize the effects of IFNTs, but IFNT paralogs
actually expressed in utero and their effects on uterine epithelial cells have not been carefully evaluated.
C-CAM1 is a secretory paralog
of C-CAM4, is expressed during hepatocyte differentiation (Cheung et al.
phagocytophilum Webster strain (AY253530 and AF443404), one msp2 paralog
of USG3 strain (AF029323), and with A.
The focus of this ERC proposal is: (i) to determine the mechanism of action and high-resolution structure of the BRCA2 tumour suppressor, and to provide a detailed picture of the interplay between BRCA2, PALB2, RAD51AP1 and the RAD51 paralogs
, in terms of RAD51 filament assembly, using biochemical, electron microscopic and cell biological approaches, (ii) to determine the biological role of a unique structure-selective tri-nuclease complex (SLX1-SLX4-MUS81-EME1-XPF-ERCC1), with particular emphasis on its roles in DNA crosslink repair and Fanconi anemia, and (iii) to understand the actions of Senataxin, which is defective in AOA2, in protecting against genome instability in neuronal cells.
Plant-derived polyphenols regulate expression of miRNA paralogs
miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.
2012) also identified key changes in Dicer domain architecture and sequence leading to specialization in either gene-regulatory or protective functions in animal and plant paralogs
The Cancer Discovery publication outlines the unique discovery process led by Blueprint Medicines' scientists to craft selective, covalent drugs to FGFR4, which historically had been a challenging kinase for drug discovery due to the sequence similarities with the other FGFR paralogs
Gene recombination between var paralogs
is the major mechanism in generation of the extreme diversity in the variant antigen repertoire (21).
Preventing the pollution of mitochondrial datasets with nuclear mitochondrial paralogs
Evolution and the Origin of Biological Information, Part 5: Paralogs
, Synteny and WGD," May 19, 2011, http:// biologos.