An intermediate-sized B cell, with a round to oval vesicular nucleus and a prominent, often central, nuleolus; usually found in the proliferative centers of chronic lymphocytic leukemia and small lymphocytic lymphoma.
Farlex Partner Medical Dictionary © Farlex 2012
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Neoplastic lymphoid infiltrates tend to be more monomorphic than reactive infiltrates: small lymphocyte-like cells are seen in small lymphocytic lymphoma/ chronic lymphocytic leukemia (Figure 5), and sometimes occasional larger blasts (paraimmunoblasts) are present.
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm of small, round, mature B lymphocytes, often admixed with prolymphocytes and paraimmunoblasts. By definition, all patients with CLL have disseminated disease with involvement of bone marrow and peripheral blood at diagnosis, with a minimal lymphocyte count of 10 000/[micro]L.