paraganglioma


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paraganglioma

 [par″ah-gang″gle-o´mah]
a tumor of the tissue composing the paraganglia.

par·a·gan·gli·o·ma

(par'ă-gang'glē-ō'mă),
A neoplasm usually derived from the chemoreceptor tissue of a paraganglion, such as the carotid body, or the medulla of the adrenal gland; the latter is usually termed a chromaffinoma or pheochromocytoma.

paraganglioma

/para·gan·gli·o·ma/ (-gang″gle-o´mah) a tumor of the tissue composing the paraganglia.
nonchromaffin paraganglioma  chemodectoma.

paraganglioma

[-gang′glē·ō′mə]
a tumor derived from the chromoreceptor tissue of a paraganglion.

paraganglioma

An uncommon neuroendocrine tumour often of the head and neck which arises in neural crest and is more common in women; 2 to 9% of carotid body, vagal body and jugulo-tympanic paragangliomas are malignant vs. 25% of those in the larynx. Paragangliomas are part of Carney’s triad (extraadrenal paraganglioma, GIST, pulmonary chondroma), and occur in von Hippel-Lindau syndrome..
 
Clinical findings
Pulsatile mass, tinnitus.

Sites
Carotid body (60%), jugulotympanic, glomus vagale.

DiffDx
Neuroendocrine tumours—e.g., carcinoid, haemangiopericytoma, neuroendocrine carcinoma, medullary carcinoma of thyroid, middle ear adenoma, meningioma.

paraganglioma

Oncology A head & neck neural crest tumor more common in ♀; 2-9% of PGs in carotid body, vagal body and jugulo-tympanic region are malignant; 25% of laryngeal PGs are malignant. See Zellballen.

par·a·gan·gli·o·ma

(par'ă-gang-glē-ō'mă)
A neoplasm usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or the medulla of the suprarenal gland; the latter is usually termed a chromaffinoma or pheochromocytoma.

par·a·gan·gli·o·ma

(par'ă-gang-glē-ō'mă)
A neoplasm usually derived from the chromoreceptor tissue of a paraganglion or the medulla of the suprarenal gland.

paraganglioma

a tumor of the tissue composing the paraganglia.
References in periodicals archive ?
1) Most such tumors arise from the adrenal medulla, while the term paraganglioma is used for this same tumor which occurs about 15% of the time in other anatomic sites.
Tim's passion and focus is on "spreading the word" about pheochromocytoma and paraganglioma because knowledge leads to more involvement in the search for a cure.
Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.
0 cm paraganglioma, consistent with a primary tumor based on location and histological findings (Figure 2b).
Significant advances have been made in determining the genetic basis of phaeochromocytomas; they are associated with the following familial syndromes: MEN-2 (activating germline mutations in the RET proto-oncogene), VHL syndrome (germline mutations in the VHL tumour suppressor gene), NF-1 (germline mutations in the NF-1 tumour suppressor gene), and phaeochromocytoma/ paraganglioma syndromes (germline mutations in the B and D subunits of mitochondrial succinate dehydrogenase--SDHB and SDHD).
Two types of paraganglioma have been reported: the former form is multiple miliary tumors, which occur with chronic lung diseases and may be found in 3.
Paragangliomas are rare, generally benign tumors that arise from cells called glomus cells, which are located along blood vessels and play a role in regulating blood pressure and blood flow.
The local distribution of paraganglioma was recently reported as: 47% jugulotympanic, 43% carotid, 10% vagal tumors.
10) reported most common cause as thymic carcinoid in 3 of 8 (37%) patients, as found in our study as well (Table III), and other well documented cases included medullary thyroid carcinoma (3), pheochromocytoma (3), medullary paraganglioma (11), pancreatic islet cell tumours (3), and tumours of the ovary (22), cervix (22) and prostrate (22).
The 39-year-old decided to take up the challenge on October 19 to raise money for Macmillan Cancer Support after discovering he had a malignant paraganglioma three months ago.
The information is presented in chapters covering benign peripheral nerve sheath tumors (neurofibromas, schwannomas, and perineuriomas); malignant peripheral nerve sheath tumors; meningioma; hemangioblastoma of the central nervous system; paraganglioma and pheochromocytoma; atypical teratoid/rhabdoid tumors of the central nervous system; neuroblastoma and related tumors; medulloblastoma, primitive neuroectodermal tumors, and pineal tumors; and key mechanisms and pathways.
Due to the synchronous nature of her lesions, genetic investigations were performed, diagnosing familial phaeochromocytoma and paraganglioma as a result of succinate dehydrogenase subunit-B mutation.