CDC73

(redirected from parafibromin)

CDC73

A gene on chromosome 1q25 that encodes a tumour suppressor involved in transcriptional and post-transcriptional control pathways, which is part of the PAF protein complex. CDC73 associates with the RNA polymerase II, subunit POLR2A, and a histone methyltransferase complex.

Molecular pathology
CDC73 mutations are associated with hyperparathyroidism (jaw tumour syndrome), familial isolated hyperparathyroidism and parathyroid carcinoma.
References in periodicals archive ?
Parafibromin will usually show a strong nuclear reaction in adenomas, compared with an absent to remarkably decreased reaction in carcinomas.
12,20) The gene encodes a protein named parafibromin for its relationship to parathyroid disease and fibro-osseous jaw lesions.
Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas.