paradoxical disinhibition

paradoxical disinhibition

An unexpected increase in aggressiveness, hostility, impulsivity, or talkativeness in a patient after treatment with a tranquilizing drug, esp. a sedative/hypnotic.
See: paradoxical excitement
References in periodicals archive ?
This crises suggest the presence of "paradoxical disinhibition" triggered by alcohol or other sedative agents in attention deficit hyperactive disorder.
Opioids most commonly inhibit release of neurotransmitters, particularly norepinephrine and acetylcholine, although in the hippocampus the result is paradoxical disinhibition, due to its impact on inhibitory interneurons.