paradoxical disinhibition
paradoxical disinhibition
An unexpected increase in aggressiveness, hostility, impulsivity, or talkativeness in a patient after treatment with a tranquilizing drug, esp. a sedative/hypnotic.
See: paradoxical excitement
References in periodicals archive
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Opioids most commonly inhibit release of neurotransmitters, particularly norepinephrine and acetylcholine, although in the hippocampus the result is paradoxical disinhibition, due to its impact on inhibitory interneurons.
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