Imaging mass spectrometry analysis showed that biologically relevant LPA species (LPA 18:1, 18:2, and 20:4) are expressed in the lymph node paracortex
at sites that are either close to or distant from HEVs and that the latter is selectively reduced in mice that are ATX deficient specifically in FRCs, (68) in agreement with the hypothesis that FRCs produce LPA by the ATX on their cell surface.
It is a highly organized structure composed of 4 main anatomic compartments: the cortex, paracortex
, medulla, and sinuses (Figure 1, A).
Histologic analysis of the lymph node showed intact architecture with an expanded paracortex
consisting almost entirely of blasts forms immunohistochemically consistent a T/myeloid mixed phenotype acute leukemia.
In the geoduck Panopea abbreviata from the Patagonian Gulf, Argentina, Paracortex
Structurally, a lymph node can be divided into three roughly concentric regions: cortex, paracortex
, and medulla, each of which supports a distinct microenvironment.
The lymph nodes in KFD exhibit a proliferative and/or necrotizing process that is often centered in the paracortex
Dermatopathic lymphadenopathy is characterized by an expanded paracortex
with small lymphocytes and scattered Langerhans cells and histiocytes, sometimes accompanied by pigment.
Multinucleate polykaryocytes were prominent in the germinal centers and in the paracortex
Normal lymph nodes are composed of cortex, paracortex
, and medulla.
Activation-induced cytidine deaminase shows staining in the centroblasts of the germinal center, with scattered large cells in the paracortex
(Figure 6, C).
The initial proliferative phase features an expanded paracortex
with increases in various histiocytes and plasmacytoid dendritic cells, which are admixed with a variable number of lymphocytes and karyorrhectic nuclear debris.