Only one case of anaplastic carcinoma of thyroid was seen where the smears showed an isolated cells and in tissue fragments extremely pleomorphic in size and shape; small-to-giant forms; nucleus large, bizarre shapes; clumped chromatin with excessive parachromatin
clearing; nucleoli large, cytoplasm abundant, pale, vacuolated, or dense.
They found that the presence of 3-dimensional cell clusters with hyperchromasia predicted the presence of at least moderate dysplasia and that parachromatin
clearing and necrosis predicted the presence of at least in situ carcinoma.
Plasma cells in the peripheral blood may reveal a range of cytological appearances varying between those of well developed plasma cells with eccentric nuclei, clumped chromatin, radially oriented parachromatin
, a distinct perinuclear hof and abundant cytoplasm; to those with lymphoplasmatic features, a high nuclear/cytoplasmic ratio, prominent nuclei, and biastic appearances virtually indistinguishable from other acute leukemias.
Individual cells were spindle shaped with clumped chromatin and parachromatin
clearing with minute conspicuous nucleoli in the background of necrosis.