paracellular transport


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par·a·cel·lu·lar trans·port

solvent movement across an epithelial cell layer through the tight junctions between cells. Compare: transcellular transport.

paracellular transport

transport of molecules around cells and through tight junctions in an epithelial cell layer.
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TJ or zonula occludens (ZO) are the first and the least permeable membrane for paracellular transport of proteins formed by several transmembrane proteins, and they connect intercellularly to one another between cells in the extracellular space.
The paracellular transport relies on intestinal permeability.
diffusional paracellular transport directly through cell-cell junctions (Hill and Shachar-Hill, 2006; Murakami et al.
11: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells.
TJs seal the intercellular spaces between cells and regulate paracellular transport of water, ions, and solutes (Proksch et al.
As claudin-1 has two extra cellular loops that display variability in the distribution and number of charged residues, it is the major determinant of ionic selectivity in paracellular transport processes (Gonzalez et al.
Therefore the enhancement of paracellular transport path is most likely to be responsible for increased passive transport of calcium in the intestine of rats fed high calcium diet.
Recently these structures that give rise to paracellular transport have been shown to contain a relatively large amount of protein.
Alessio Fasano, zonulin appears to be involved in many disease states in which leakage occurs via paracellular transport across epithelial and endothelial tight junctions (tj), and thus may play an important potential role in the treatment of autoimmune diseases.
The adjacent cells adhere through tight junctions formed at the apical side of the monolayer, which can discriminate the transcellular and paracellular transport of drugs across the epithelial layer (Yamashita et al.
However, up to now it has not been fully revealed whether the increased macromolecular passage is mainly due to transcellular or paracellular transport.