paracellular transport


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par·a·cel·lu·lar trans·port

solvent movement across an epithelial cell layer through the tight junctions between cells. Compare: transcellular transport.
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TJ proteins are dysregulated or can be genetically defective in numerous diseases, which may lead to three effects: i) impaired paracellular transport causing magnesium loss in the kidney, ii) increased paracellular transport of solutes and water causing leak-flux diarrhea, and iii) increased permeability to large molecules (23).
Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2[alpha] mediated changes in the expression of occludin and ZO-1
To evaluate functionality of the diffusional barrier in more detail, the transport of sodium fluorescein (NaFlu), a hydrophilic molecule typically used to evaluate paracellular transport, was monitored.
Co-Culture of Human Alveolar Epithelial (hAELVi) and Macrophage (THP-1) Cell Lines
TJ is generated by the assembly of multiple proteins located near the apical part of the epithelium between neighboring cells (Figure 2) and controls the permeability of the paracellular transport pathway.
Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals
Food and nutrients are absorbed into enterocytes and later the capillaries via transcellular and paracellular transport. Sugar absorption studies show an increased absorption of transfer proteins in the small and large bowel, suggesting disruption of the intestinal membrane [2].
Advanced Biventricular Heart Failure due to Left Ventricular Noncompaction Cardiomyopathy Leading to the Formation of a Gastric Bezoar: The Implications of Heart Failure on the Gastrointestinal Tract
TJ or zonula occludens (ZO) are the first and the least permeable membrane for paracellular transport of proteins formed by several transmembrane proteins, and they connect intercellularly to one another between cells in the extracellular space.
Nanocarriers: Novel Approaches to Oral Delivery of Insulin/Nanotasiyicilar: Oral Insulin Tedavisine Yeni Yaklasimlar
Previously, it was reported that gliadin crosses the epithelium through paracellular transport. The paracellular transport relies on intestinal permeability.
Effect of Gluten Containing Diet on Pristane Induced Lupus Prone Mice
However, it is still controversial as to which degree other routes of water transport play a role, e.g., diffusional paracellular transport directly through cell-cell junctions (Hill and Shachar-Hill, 2006; Murakami et al., 2006; Fishbarg, 2010) and secondary active water transport through cotransporters for ions and metabolites (see Zeuthen, 2002).
Water transport and functional dynamics of aquaporins in osmoregulatory organs of fishes
11: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells.
Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier
[27] reported that the paracellular transport of metformin was saturable, and perhaps coadministration of metformin and fiber saturated paracellular transport.
Evaluation of the association metformin: Plantago ovata husk in diabetic rabbits
TJs seal the intercellular spaces between cells and regulate paracellular transport of water, ions, and solutes (Proksch et al.
Effects of in utero exposure of C57bl/6J mice to 2,3,7,8-tetrachlorodibenzop-dioxin on epidermal permeability barrier development and function
As claudin-1 has two extra cellular loops that display variability in the distribution and number of charged residues, it is the major determinant of ionic selectivity in paracellular transport processes (Gonzalez et al., 2008).
Effect of glucagon-like peptide 2 on tight junction in jejunal epithelium of weaned pigs though MAPK signaling pathway
Therefore the enhancement of paracellular transport path is most likely to be responsible for increased passive transport of calcium in the intestine of rats fed high calcium diet.
Influence of dietary calcium content on intestinal permeability in rat

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