Ablation of MMP9 gene ameliorates paracellular
permeability and fibrinogen-amyloid beta complex formation during hyperhomocysteinemia.
Mechanistic studies of intestinal transport: p-glycoprotein (g-pg), paracellular
permeability, cholesterol transporters
It has loosening effect on the tight junction of intestinal epithelial cells, allowing the inflow of Ca like nutrients via paracellular
pathway (Ballard et al.
TJs seal the intercellular spaces between cells and regulate paracellular
transport of water, ions, and solutes (Proksch et al.
space between the endothelial cells of the BBB is protected by an extensive network of tight junctions, consisting of transmembrane proteins that include occludin, claudin, and junction adhesion molecule (JAM), as well as cytoplasmic proteins, specifically zonulin-1 (Z01), zonulin-2 (Z02), and zonulin-3 (Z03).
23] It has been demonstrated that intestinal paracellular
absorption in patients with active pulmonary TB is markedly decreased, but that this is unlikely to contribute significantly to lower plasma levels, as it represents less than 5% of the total absorptive area of the small intestine.
barrier BC090128 Marker name Organism e Value HmC2040_1251 Haliotis discus 1.
space) must be sealed to maintain this barrier function.
These systems should also possess a longer life time when serving as a drug carrier and should support paracellular
transport of the drug molecules inside the body .
H2O2 induces paracellular
permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway.
77 The exposure of the esophageal epithelium to reflux induces a paracellular
permeability that results morphologically in dilated intercellular spaces, which can be seen in both ERD and NERD.
Decreased transepithelial resistance and increased flux of paracellular
marker such as mannitol and raffinose (98) indicate the disruption of the tight junction.