The IHC staining of p53 was negative in the normal basal and parabasal cells
of the normal cervical squamous epithelium.
independently reviewed and graded each slide of the 18 for the presence of the following characteristics: any histiocytes, stripped nuclei or nuclear streaks, intermediate and/or superficial squamous cells, neutrophils (0100 per X400 field, 101-1000 per X400 field, or >1000 per X400 field), degenerating parabasal cells
greater than 100, background debris involving more than 25% of the cellular area, and pseudoparakeratotic cells greater than 100.
After 2 weeks, all 3 doses of DHEA induced a decrease in the percentage of parabasal cells
(indicating histologic improvement in vaginal atrophy), a significant reduction in vaginal pH, and a significant improvement in the most bothersome vaginal symptom (e.
The 30 mg and 60 mg dose both improved pH, superficial and parabasal cells
on maturation index in a statistically significant fashion compared to placebo as early as 4 weeks and at 12 weeks.
Positive staining in parabasal cells
is found under normal conditions, so interpreting the results of this stain rests on examination of the middle and upper thirds of the squamous epithelium.
A wet mount shows a marked increase in neutrophils with scattered parabasal cells
A wet mount shows parabasal cells
and no lactobacilli.
Lichen planus is characterized by purulent discharge that contains bacteria, white blood cells, and parabasal cells