para-aminosalicylic acid

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Related to para-aminosalicylic acid: Sodium aminosalicylate

p-aminosalicylic acid

(PAS) (PASA) [ah-me″no-sal-ĭ-sil´ik]

an analogue of p-aminobenzoic acid that inhibits folic acid synthesis in Mycobacterium tuberculosis, used in the treatment of tuberculosis, administered orally. In pharmacy it is officially called aminosalicylic acid. It enhances the potency of streptomycin and delays the development of bacilli resistant to streptomycin. Gastrointestinal irritation accompanied by anorexia, nausea, and vomiting may be reduced by administering the drug with food at mealtime.

para-aminosalicylic acid

(păr′ə-ə-mē′nō-săl′ĭ-sĭl′ĭk, ăm′ə-nō-)

n. Abbr. PAS

A bacteriostatic agent, C₇H₇NO₃, prescribed for the treatment of tuberculosis. Also called aminosalicylic acid.

para-aminosalicylic acid (PAS)

A drug formerly widely used to treat pulmonary TUBERCULOSIS but now superceded by more effective antibiotics. The drug is on the WHO official list.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

References in periodicals archive ?

Vander Heyden et al., "Quantitative determination of para-aminosalicylic acid and its degradation product meta-aminophenol in pellets by ionpair high-performance liquid chromatography applying the monolithic Chromolith Speedrod RP-18e column," Biomedical Chromatography, vol.

Zeng, "HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues," Journal of Pharmaceutical and Biomedical Analysis, vol.

Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid--zinc layered hydroxide nanocomposites

The intrinsic reproducibility of phenotypic DST for several drugs tested routinely including ethambutol, thioamides, cycloserine, and para-aminosalicylic acid is poor.

Additional drug resistance of multidrug-resistant tuberculosis in patients in 9 countries

Acquired resistance to capreomycin was significantly associated with receiving the following drugs or drug groups: <3 effective drugs (p = 0.008), an ineffective fluoroquinolone (p = 0.009), or ineffective para-aminosalicylic acid (p = 0.02).

Risk factors for acquisition of drug resistance during multidrug-resistant tuberculosis treatment, Arkhangelsk Oblast, Russia, 2005-2010

Routine DST for pyrazinamide, kanamycin, cycloserine, and para-aminosalicylic acid was not performed.

Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa

Fluoroquinolones had the highest rate of resistance (16.4%), followed by capreomycin (5.7%), para-aminosalicylic acid (3.7%), and amikacin (3.2%).

Laboratory-based surveillance of extensively drug-resistant tuberculosis, China

A regimen with rifabutin, ciprofloxacin, amikacin, para-aminosalicylic acid, and clofazimine led to a short phase of negative sputum cultures, but a chest X-ray showed no improvement.

Double Infection with a Resistant and a Multidrug-Resistant Strain of Mycobacterium tuberculosis

We identified all dispensings of isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, ethionamide, kanamycin, cycloserine, capreomycin, and para-aminosalicylic acid (PAS).