papillary renal cell carcinoma


Also found in: Acronyms.

papillary renal cell carcinoma

the second most common form of renal cell carcinoma, accounting for approximately 15% of all renal malignancies; histologically similar to papillary carcinomas in other organs. Histogenetically and genetically, it is distinct from clear cell renal carcinoma. It is found in 80% of people who have a tuberous sclerosis.

PRCC

A gene on chromosome 1q21.1 that encodes a protein thought to play a role in pre-mRNA splicing.

Molecular pathology
PRCC translocation (X;1)(p11;q21) to TFE3 is associated with papillary renal cell carcinoma.
References in periodicals archive ?
A, Type 1 papillary renal cell carcinoma with well-formed fibrovascular core lined with a single layer of cuboidal cells with moderate amphophilic cytoplasm.
Within this context, this case report aims to highlight the pathological characteristics of this rare subtype of renal cell tumors and to point out the differential diagnosis--particularly with the papillary renal cell carcinoma, given the different prognosis and therapeutic approach of these two entities.
All the radical nephrectomy specimens diagnosed as renal cell carcinoma included clear cell renal cell carcinoma 21 (70%) cases clear cell papillary renal cell carcinoma 03 (10%) papillary renal cell carcinoma 02 (6.7%) cases and 04 (13.3%) hybrid cases showing a mixed pattern of tumors in which three cases show a combination of clear cell with focal oncocytic pattern and papillary arrangement and one case revealing combination of clear cell with papillary arrangement with foci of chromophobe pattern.
A case of acquired renal cystic disease (ACDK) with oncocytosis, a dominant nodule (oncocytoma), multiple adenomas and a microscopic papillary renal cell carcinoma associated with crescentic glomerulonephritis.
"Activation of MET by mutation or amplification is associated with disease progression and poor prognosis in a significant number of patients with papillary renal cell carcinoma, gastric cancer, and head and neck cancer," said Morrissey.
H&E photomicrographs of different subtypes of RCCs at 400X magnification: (a) Low Grade (Grade 1) Clear Cell Renal Cell Carcinoma (b) High Grade (Grade 4) Clear Cell Renal Cell Carcinoma (c) Papillary Renal Cell Carcinoma (d) Chromophobe Renal Cell Carcinoma
Varela et al., "Synchronous collecting duct carcinoma and papillary renal cell carcinoma: A case report and review of the literature," Anticancer Reseach, vol.
Although the characterization and grouping of hRCC is evolving, we have limited our recommendations to those hRCC in which renal tumours are a prominent clinical presentation and various recommendations are available, including: von Hippel Lindau syndrome (VHL), hereditary papillary renal cell carcinoma (HPRC), hereditary leiomyomatosis renal cell carcinoma (HLRCC), Birt-Hogg-Dube syndrome (BHD), hereditary paragangliomas-pheochromocytoma syndromes (SDHB/SDHC/SDHD) and tuberous sclerosis complex (TSC).
We present a case of a 34-year-old young male patient who presented with papillary renal cell carcinoma (PRCC) in the native kidney 5 years post- renal transplantation.
Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma. Cancer Res 2007;67:3171-6.
The most common histological diagnosis in adults was conventional renal cell carcinoma in 172 (73%) patients followed by papillary renal cell carcinoma in 20 (8.5%) patients.

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