papillary renal cell carcinoma

Also found in: Acronyms.

papillary renal cell carcinoma

the second most common form of renal cell carcinoma, accounting for approximately 15% of all renal malignancies; histologically similar to papillary carcinomas in other organs. Histogenetically and genetically, it is distinct from clear cell renal carcinoma. It is found in 80% of people who have a tuberous sclerosis.


A gene on chromosome 1q21.1 that encodes a protein thought to play a role in pre-mRNA splicing.

Molecular pathology
PRCC translocation (X;1)(p11;q21) to TFE3 is associated with papillary renal cell carcinoma.
References in periodicals archive ?
A case of acquired renal cystic disease (ACDK) with oncocytosis, a dominant nodule (oncocytoma), multiple adenomas and a microscopic papillary renal cell carcinoma associated with crescentic glomerulonephritis.
Papillary renal cell carcinoma within a renal oncocytoma: Case report of very rare coexistence.
2 translocation carcinoma Positive for CD10, RCCM, TFE3, PAX2, PAX8, and cathepsin-K Usually negative or focally positive for AE1/AE3 Clear cell papillary renal cell carcinoma Positive for CK7, PAX2, and PAX8 Negative for AMACR, RCCM, and CD10 Urothelial carcinoma Positive for HMWCK, CK7, p63, CK5/6, CK20, uroplakin III, thrombomodulin, and GATA-3 Negative for RCCM, CD10, PAX2, and PAX8 Myoid-rich or epithelioid angiomyolipoma Positive for HMB-45, Melan-A, MSA, or SMA Negative for AE1/AE3, CD10, RCCM, PAX2, and PAX8 Abbreviations: AMACR, [alpha]-methylacyl-coenzyme A racemase; CAIX, carbonic anhydrase IX; CK, cytokeratin; HMWCK, high-molecular-weight cytokeratin; MSA, muscle-specific actin; RCCM, renal cell carcinoma marker; SMA, smooth muscle actin.
A) On hematoxylin-eosin (H&E) staining (x40), papillary renal cell carcinoma (RCC) (arrow) within the renal oncocytoma (arrowhead).
Fusion of splicing factor genes PSF and NonO(p54nrb) to the TFE3 gene in papillary renal cell carcinoma.
The multi-center open-label phase 2 study is designed to enroll up to 34 patients with hereditary or sporadic papillary renal cell carcinoma.
Lymphopenia as an independent predictor of worse survival in papillary renal cell carcinoma.
Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma.
Metastasis from papillary renal cell carcinoma masquerading as primary ovarian clear cell tumor.
Papillary renal cell carcinoma (RCC) is an established subtype of RCC with characteristic histologic, immunohistochemical, and cytogenetic features that separate it from other types of RCC.
Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

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